Biochemical effects of luxabendazole on Trichinella spiralis.

A Criado-Fornelio, C de Armas-Serra, A Jimenez-Gonzalez, N Casado-Escribano, F Rodriguez-Caabeiro

Index: Parasitol. Res. 76(6) , 518-20, (1990)

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Abstract

Biochemical changes produced by luxabendazole in muscle-stage Trichinella spiralis larvae consisted of a decrease in free glucose and glycogen levels (46.71% and 35.66%, respectively) after in vivo treatment, slight in vitro inhibition of fumarate reductase activity (24.15%) and, finally, inhibition of [3H]-colchicine-tubulin binding, which was found to be of a competitive nature, with an inhibition constant (Ki) of 0.9 x 10(-7) M. In a parallel study, luxabendazole did not appear to be inhibitory to [3H]-colchicine binding to pig-brain tubulin.