Synthesis of quinazolines and tetrahydroquinazolines: copper-catalyzed tandem reactions of 2-bromobenzyl bromides with aldehydes and aqueous ammonia or amines.

Xuesen Fan, Bin Li, Shenghai Guo, Yuanyuan Wang, Xinying Zhang

Index: Chem. Asian J. 9(3) , 739-43, (2014)

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Abstract

An efficient synthesis of diversely substituted quinazolines and 1,2,3,4-tetrahydroquinazolines through copper-catalyzed tandem reactions of the readily available 2-bromobenzyl bromides, aldehydes, and aqueous ammonia or amines has been developed. By using ammonia and simple aliphatic amines as the nitrogen source, the present method provides a versatile and practical protocol for the synthesis of quinazolines and 1,2,3,4-tetrahydroquinazolines. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.