Dimerization of human growth hormone in the presence of metal ions.

G Dienys, J Sereikaite, V Luksa, O Jarutiene, E Mistiniene, V A Bumelis

Index: Bioconjug. Chem. 11(5) , 646-51, (2000)

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Abstract

Zn(2+) and Co(2+) ions are known to promote human growth hormone reversible dimerization. In these studies, dimerization was also shown to be initiated by nine other metal ions: Cd(2+), Hg(2+), Cu(2+), Ag+, Au(3+), Au+, Pd(2+), Ni(2+), and Pt(4+). In some cases (Hg(2+), Ag(+), Au(3+), and Ni(2+)) formation of higher oligomers also took place. In addition further detailed investigation of dimerization in the presence of Zn(2+) ions was carried out.