Controlling mode selectivity in palladium-catalyzed bisdiene carbocyclizations: optimizing for cyclization-trapping over cycloisomerization.

James M Takacs, Scott D Schroeder, Jianxin Han, Meg Gifford, Xun-Tian Jiang, Twana Saleh, Suresh Vayalakkada, Amy H Yap

Index: Org. Lett. 5(20) , 3595-8, (2003)

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Abstract

[reaction: see text] Screening combinations of five catalyst precursors with 13 phosphorus ligands identified cyclization catalysts that favor carbocyclization-trapping with N-hydroxyphthalimide over a competing cycloisomerization mode.