Endocrine effects of domperidone: a peripheral dopamine blocking agent.

G M Brown, H Verhaegan, T B Van Wimersma Greidanus, J Brugmans

Index: Clin. Endocrinol. (Oxf.) 15(3) , 275-82, (1981)

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Abstract

In the present study, effects of domperidone, a peripheral dopamine blocking agent, on prolactin and growth hormone were examined to determine whether dopamine regulation of these hormones involved structures external to the blood-brain barrier. A clearcut elevation in prolactin was produced by domperidone. GH response to apomorphine was partially blocked by domperidone.