Experimental sensitization of guinea pigs by drugs. Comparison of the maximization test with the wholly intradermal test.

F Rantuccio, C Coviello, D Sinisi, A Scardigno, A Conte

Index: Contact Dermatitis 9(6) , 479-83, (1983)

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Abstract

The capacity of tegobetain, pyrrolnitrin, tolcyclate and chlorquinaldol to induce delayed-type contact sensitization was studied in guinea pigs in 2 series of tests using the method of Magnusson & Kligman and the authors' modification of the wholly intradermal Draize technique. Histological examination of skin biopsies obtained from the test area demonstrated that tegobetain, pyrrolnitrin and tolcyclate are potential sensitizers.