Highly enantioselective amide ligation by prior thiol capture

DS Kemp, DR Buckler

Index: Kemp, D. S.; Buckler, David R. Tetrahedron Letters, 1991 , vol. 32, # 26 p. 3013 - 3016

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Citation Number: 9

Abstract

For 2 R - Ac, X = Boc-L-Cys(S)-OMe TLC R f = 0.40 (2:1 hexane/EtOAc); 2 R = ZL-Ala X = Boc-L-Cys(S)-OMe TLC R f = 0.29 (2:1 hexane/EtOAc); HRMS: (M+H)+ Calcd for C 23 H 26 N 7 S 3 : 524.0871; Found: 524.0872; 3ab X - Boc-L-Cys(5)-OMe HPLC RP C 18 40 %