Physico-chemical characterization of a new salt of ibuprofen.

M S Suleiman, N M Najib, M A Hassan, M E Abdel-Hamid

Index: J. Pharm. Biomed. Anal. 8(4) , 321-7, (1990)

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Abstract

A new salt of ibuprofen was prepared by reaction with t-butylamine; its formation was confirmed by IR and 1H-NMR spectroscopy. The salt was characterized by thermoanalytical, X-ray powder diffraction and solubility studies. The salt was found to be 1.5 times more soluble in water than was ibuprofen, with an enthalpy of solution of -8.84 kcal mol-1.