Total synthesis of 10-norparvulenone and of O-methylasparvenone using a xanthate-mediated free radical addition-cyclization sequence.

Alejandro Cordero Vargas, Béatrice Quiclet-Sire, Samir Z Zard

Index: Org. Lett. 5(20) , 3717-9, (2003)

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Abstract

[reaction: see text] A short synthesis of (+/-)-10-norparvulenone and (+/-)-O-methylasparvenone was developed starting from commercially available m-methoxyphenol, hinging on a xanthate-mediated addition-cyclization sequence for the construction of the alpha-tetralone subunit.