Structural basis for the potent calpain inhibitory activity of peptidyl alpha-ketoacids.

Isaac O Donkor, Haregewein Assefa, Jiuyu Liu

Index: J. Med. Chem. 51(14) , 4346-50, (2008)

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Abstract

A series of peptidyl alpha-ketoacids and alpha-ketoesters was synthesized and studied as mu-calpain inhibitors. Docking studies revealed that the mu-calpain inhibitory activity of the compounds is influenced by hydrogen bonding interactions and the potential for ionic interaction with active site residues as well as placement of a planar N-terminal capping group into the S 3 pocket of the enzyme.