Is the induction of neuroblastoma differentiation by CCA mediated by its effects on the electrochemical gradient?

J L Vayssière, F Berthelot, F Gros, B Croizat

Index: FEBS Lett. 173(1) , 19-22, (1984)

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Abstract

Various mitochondrial inhibitors are tested in neuroblastoma cells. Their effects on the mit-proteins and some cytoskeletal proteins are compared to those of CCA, a differentiation inducer. This comparison favours the hypothesis that the primary effect of CCA induction is an alteration of the electrochemical gradient.