Electrokinetic probes for single-step screening of polyol stereoisomers: the virtues of ternary boronate ester complex formation.

Claire Kaiser, Giselle Segui-Lines, Jason C D'Amaral, Adam S Ptolemy, Philip Britz-McKibbin

Index: Chem. Commun. (Camb.) (3) , 338-40, (2008)

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Abstract

Electrokinetic probes based on the differential migration of ternary boronate ester complexes permit the selective analysis of micromolar levels of UV-transparent polyol stereoisomers in urine samples via dynamic complexation-capillary electrophoresis that is applicable to single-step screening of in-born errors of sugar metabolism, such as galactosemia.