Structure--activity relationships of azasugar-based MMP/ADAM inhibitors.

Hideki Moriyama, Takahiro Tsukida, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino, Shin-ichiro Nishimura

Index: Bioorg. Med. Chem. Lett. 13(16) , 2737-40, (2003)

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Abstract

In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.