CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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KV9400000
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CHEMICAL NAME :
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Ethylene, 1,2-dichloro-, (E)-
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CAS REGISTRY NUMBER :
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156-60-5
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BEILSTEIN REFERENCE NO. :
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1420761
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LAST UPDATED :
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199803
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DATA ITEMS CITED :
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24
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MOLECULAR FORMULA :
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C2-H2-Cl2
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MOLECULAR WEIGHT :
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96.94
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WISWESSER LINE NOTATION :
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G1U1G -T
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Human
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DOSE/DURATION :
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4800 mg/m3/10M
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TOXIC EFFECTS :
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Behavioral - sleep Behavioral - hallucinations, distorted perceptions
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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1235 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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7411 mg/kg
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TOXIC EFFECTS :
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Cardiac - other changes Lungs, Thorax, or Respiration - other changes Liver - fatty liver degeneration
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2122 mg/kg
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TOXIC EFFECTS :
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Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - ataxia
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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75 gm/m3/2H
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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3952 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LCLo - Lowest published lethal concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Mammal - cat
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DOSE/DURATION :
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43 gm/m3/6H
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TOXIC EFFECTS :
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Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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>5 gm/kg
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TOXIC EFFECTS :
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Skin and Appendages - dermatitis, irritative (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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113 gm/kg/90D-C
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - changes in bladder weight
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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200 ppm/8H/16W-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - other changes Liver - other changes Endocrine - changes in endocrine weight (unspecified)
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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6000 ppm/6H
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SEX/DURATION :
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female 7-16 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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DOSE :
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12000 ppm/6H
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SEX/DURATION :
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female 7-16 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
MUTATION DATA
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TYPE OF TEST :
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Sex chromosome loss and nondisjunction
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TEST SYSTEM :
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Rodent - hamster Lung
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DOSE/DURATION :
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6500 umol/L
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REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987
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