S 18986
Modify Date: 2025-09-18 17:44:42
S 18986 structure
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Common Name | S 18986 | ||
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| CAS Number | 175340-20-2 | Molecular Weight | 224.27900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H12N2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of S 18986S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests[1][2]. |
| Name | (3aS)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide |
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| Description | S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests[1][2]. |
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| Related Catalog | |
| In Vivo | S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 shows antiamnesic properties in middle-aged rodents in spatial memory models [1]. S 18986 (5-50 mg/kg; i.p.) significantly increases both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation[1]. Animal Model: Middle-aged (14-15-months-old) mice[1] Dosage: 0.3, 1, and 10 mg/kg Administration: p.o. Result: Showed antiamnesic properties in middle-aged rodents. |
| References |
| Molecular Formula | C10H12N2O2S |
|---|---|
| Molecular Weight | 224.27900 |
| Exact Mass | 224.06200 |
| PSA | 57.79000 |
| LogP | 2.37940 |
| InChIKey | MNTIJYGEITVWHU-SNVBAGLBSA-N |
| SMILES | O=S1(=O)NC2CCCN2c2ccccc21 |
| Storage condition | -20°C |
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Name: Human GluA2 (Ionotropic glutamate receptors)
Source: IUPHAR-DB
Target: GluA2 (Ionotropic glutamate receptors) [Homo sapiens]
External Id: 445_Human
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Name: Human GluA4 (Ionotropic glutamate receptors)
Source: IUPHAR-DB
Target: GluA4 (Ionotropic glutamate receptors) [Homo sapiens]
External Id: 447_Human
|
|
Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
|
|
Name: Human GluA3 (Ionotropic glutamate receptors)
Source: IUPHAR-DB
Target: GluA3 (Ionotropic glutamate receptors) [Homo sapiens]
External Id: 446_Human
|
|
Name: Human GluA1 (Ionotropic glutamate receptors)
Source: IUPHAR-DB
Target: GluA1 (Ionotropic glutamate receptors) [Homo sapiens]
External Id: 444_Human
|
|
Name: Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes asses...
Source: ChEMBL
Target: N/A
External Id: CHEMBL889555
|
|
Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
|
|
Name: Increase in (S)-AMPA-stimulated [3H]noradrenaline release in Wistar rat hippocampus a...
Source: ChEMBL
Target: Hippocampus
External Id: CHEMBL889557
|
|
Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
|
|
Name: Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes asses...
Source: ChEMBL
Target: N/A
External Id: CHEMBL889552
|
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