| Identification | Back Directory | [Name]
(3-Oxo-3,4-dihydro-2H-benzo[b]-[1,4]oxazin-6-yl)boronic acid | [CAS]
1246765-28-5 | [Synonyms]
(3-Hydroxy-2H-1,4-benzoxazin-6-yl)boronic Acid
Boronic acid, B-(3,4-dihydro-3-oxo-2H-1,4-benzoxazin-6-yl)-
(3-Oxo-3,4-dihydro-2H-benzo[b]-[1,4]oxazin-6-yl)boronic acid
(3-Oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)boronic acid (contains varying amounts of Anhydride) | [Molecular Formula]
C8H8BNO4 | [MDL Number]
MFCD16036561 | [MOL File]
1246765-28-5.mol | [Molecular Weight]
192.96 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
8.06±0.20(Predicted) | [Appearance]
Light yellow to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
Step 2: 3-Oxo-2H,4H-benzo[b][1,4]oxazine-6-boronic acid pinacol ester (500 mg, 1.82 mmol), polymer-loaded phenylboronic acid (2200 mg, 6.4 mmol), and 1M aqueous hydrochloric acid solution (132 mg, 3.63 mmol) were mixed in acetonitrile (12 mL) and stirred at room temperature. After completion of the reaction, the reaction mixture was filtered and the filtrate concentrated to afford (3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)boronic acid as a solid (232 mg, 66% yield). The product was characterized by 1H NMR (400 MHz, methanol-d4): δ 4.79 (2H, s), 6.94 (1H, d, J = 8.0 Hz), 7.18 (1H, d, J = 1.2 Hz), 7.27 (1H, dd, J = 8.0,1.4 Hz). | [References]
[1] Patent: WO2010/116282, 2010, A1. Location in patent: Page/Page column 56 |
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