| Identification | Back Directory | [Name]
SELICICLIB | [CAS]
186692-44-4 | [Synonyms]
(+/-)-ROSCOVITINE
(Rac)-Roscovitine
2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol
2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-Butanol
1-Butanol, 2-[[9-(1-methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]- | [Molecular Formula]
C19H26N6O | [MDL Number]
MFCD02266401 | [MOL File]
186692-44-4.mol | [Molecular Weight]
354.45 |
| Hazard Information | Back Directory | [Uses]
(Rac)-Roscovitine ((Rac)-Seliciclib) is a selective cyclin-dependent kinases (CDKs) inhibitor. (Rac)-Roscovitine binds to the active sites of CDKs competitively with ATP, inhibiting the phosphorylation activity of CDKs. (Rac)-Roscovitine induces apoptosis in cancer cells. (Rac)-Roscovitine is promising for research of cancers or other diseases associated with CDK dysregulation, such as neurodegenerative diseases, cardiac disorders, viral and protozoan infections, glomerulonephritis, and chronic inflammation[1]. | [References]
[1] Jorda R, et al. Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity. J Med Chem. 2011 Apr 28;54(8):2980-93. |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
http://www.invivochem.cn/ |
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