| Identification | Back Directory | [Name]
Fluorescein-PEG6-Acid | [CAS]
2055014-69-0 | [Synonyms]
5-FITC-?PEG6-?COOH
Flurescein-PEG6-COOH
Fluorescein-PEG6-Acid
Fluorescein-thiourea-PEG6-acid
4,7,10,13,16,19-Hexaoxa-22-azatricosanoic acid, 23-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)amino]-23-thioxo- | [Molecular Formula]
C36H42N2O13S | [MDL Number]
MFCD28505584 | [MOL File]
2055014-69-0.mol | [Molecular Weight]
742.79 |
| Chemical Properties | Back Directory | [Boiling point ]
917.7±75.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF, DCM | [pka]
4.28±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Fluorescein-PEG6-Acid is a xanthene dye with excitation/emmission maximum 494/517 nm and a free terminal carboxyl acid. Terminal carboxylic acid can react with primary amine groups in the presence of of activators (e.g. EDC, or HATU) to form a stable amide bond. It be used as quantum yield standard. Hydophilic PEG spacer increases solubility in aqueous media and reduces steric hindrance during binding. | [Uses]
Fluorescein-thiourea-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Alfa Chemistry
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1-516-6625404 |
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http://www.alfa-chemistry.com |
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