| Identification | Back Directory | [Name]
1,2,4-Triazolo[4,3-a]pyrimidine-3-carboxylic acid, 1-[4-(aminosulfonyl)phenyl]-1,5-dihydro-7-methyl-5-oxo-, 2-(4-pyridinylmethylene)hydrazide | [CAS]
2389034-45-9 | [Synonyms]
HCAIX-IN-2
1,2,4-Triazolo[4,3-a]pyrimidine-3-carboxylic acid, 1-[4-(aminosulfonyl)phenyl]-1,5-dihydro-7-methyl-5-oxo-, 2-(4-pyridinylmethylene)hydrazide | [Molecular Formula]
C19H16N8O4S | [MOL File]
2389034-45-9.mol | [Molecular Weight]
452.45 |
| Hazard Information | Back Directory | [Uses]
HCAIX-IN-2 (compound 9d) is a selective carbonic anhydrase inhibitor with the Ki values of 24.6 nM and 45.3 nM for hCA IX and hCA XII, respectively[1]. | [IC 50]
CA I: 2481 nM (Ki); hCA II: 456.2 nM (Ki); hCA IX: 24.6 nM (Ki); hCA XII: 45.3 nM (Ki) | [References]
[1] Mohamed A Said, et al. Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase inhibitors. Eur J Med Chem. 2020 Jan 1;185:111843. DOI:10.1016/j.ejmech.2019.111843 |
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