| Identification | Back Directory | [Name]
BMS 564929 | [CAS]
627530-84-1 | [Synonyms]
929
BMS-564
BMS 564929
BMS 564929;BMS564929
BMS-564929;BMS-564;929; BMS 564929
2-chloro-4-((7R,7aS)-7-hydroxy-1,3-dioxotetrahydro-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl)-3-methylbenzonitrile
2-Chloro-3-methyl-4-[(7R,7aS)-tetrahydro-7-hydroxy-1,3-dioxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl]benzonitrile
Benzonitrile, 2-chloro-3-methyl-4-[(7R,7aS)-tetrahydro-7-hydroxy-1,3-dioxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl]- | [Molecular Formula]
C14H12ClN3O3 | [MDL Number]
MFCD15146692 | [MOL File]
627530-84-1.mol | [Molecular Weight]
305.72 |
| Chemical Properties | Back Directory | [Boiling point ]
523.3±60.0 °C(Predicted) | [density ]
1.58±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 50 mg/mL (163.55 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
neat | [pka]
13.38±0.20(Predicted) | [color ]
White to off-white | [BRN ]
11053870 | [Major Application]
forensics and toxicology
pharmaceutical (small molecule) | [InChI]
1S/C14H12ClN3O3/c1-7-9(3-2-8(6-16)11(7)15)18-13(20)12-10(19)4-5-17(12)14(18)21/h2-3,10,12,19H,4-5H2,1H3/t10-,12+/m1/s1 | [InChIKey]
KEJORAMIZFOODM-PWSUYJOCSA-N | [SMILES]
O=C([C@@]1([H])N2CC[C@H]1O)N(C3=C(C)C(Cl)=C(C#N)C=C3)C2=O |
| Hazard Information | Back Directory | [Uses]
BMS-564929 is a selective androgen receptor modulator that induces anabolic effects. Potential use in osteoporosis treatments; SARMs | [in vivo]
In sexually mature, castrated male rats, a well-characterized animal model, BMS-564929 (p.o.) shows substantially more potent activity in the levator ani, exhibiting an ED50 of 0.0009 mg/kg in the levator ani and an ED50 of 0.14 mg/kg in the prostate; a net 160-fold selectivity for muscle vs. prostate. Approximately 100% muscle stimulation is achieved at 0.1 mg/kg, reaching greater than 125% stimulation at 0.3 and 1 mg/kg. Compared with T propionate (TP) in the same model, BMS-564929 is more than 200 times more potent in stimulation of muscle and 80 times more selective for muscle vs. prostate[1]. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
http://www.bocsci.com |
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