| Identification | Back Directory | [Name]
Chonglou Saponin VII | [CAS]
68124-04-9 | [Synonyms]
Paris VII
Dioscinin
Chonglouoside Ⅶ
Paris saponin VII
Chonglou saponin Ⅶ
Chonglou Saponin VII
β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[O-6-deoxy-α-L-mannopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→4)]- | [Molecular Formula]
C51H82O21 | [MDL Number]
MFCD20260362 | [MOL File]
68124-04-9.mol | [Molecular Weight]
1031.2 |
| Chemical Properties | Back Directory | [Melting point ]
243-245 °C (decomp) | [density ]
1.45±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light | [solubility ]
Soluble in methanol; | [form ]
powder | [pka]
12?+-.0.70(Predicted) | [color ]
White | [Water Solubility ]
sparingly soluble in water |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents. | [Uses]
Used for content determination/identification/pharmacological experiments, etc. | [Biological Activity]
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with inhibition of Akt/p38 MAPK and P-gp. It attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochrome c), and reduces the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1 and p-Akt. Paris saponin VII induces strong autophagy in K562/ADR cells, which can be used for leukemia research. | [Pharmacology]
Chonglou saponin VII has the functions of anti-inflammatory, anti-tumor, anti-viral, lowering cholesterol, lowering blood pressure and so on. | [in vitro]
Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. It significantly suppresses cell proliferation by cell cycle arrest in the G0 /G1 phase. | [in vivo]
Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice. | [target]
| Akt | p38 | Bcl-2 | Caspase-9 | Caspase-3 | PARP-1 | |
|
|