| Identification | Back Directory | [Name]
K-Ras-IN-1 | [CAS]
84783-01-7 | [Synonyms]
Mdk-3017
K-Ras-IN-1
K-Ras inhibitor 1
2-(Pyrrolidine-1-carbothioyl)phenol
(2-Hydroxy-phenyl)-pyrrolidin-1-yl-methanethione
Methanethione, (2-hydroxyphenyl)-1-pyrrolidinyl- | [Molecular Formula]
C11H13NOS | [MDL Number]
MFCD02193415 | [MOL File]
84783-01-7.mol | [Molecular Weight]
207.29 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMSO : ≥ 28 mg/mL (135.08 mM) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
K-Ras-IN-1 is the inhibitor for K-Ras by occupying the binding site of son of sevenless (Sos), preventing the interaction between Sos and K-Ras, inhibiting the Sos-catalyzed GDP to GTP exchange process. K-Ras-IN-1 is promising for research of pancreatic, colon and lung cancer[1][2]. | [References]
[1] Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54(2):530-538. DOI:10.1021/ci400474u
[2] Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-3. DOI:10.1002/anie.201201358 |
|
|