环丙基萘啶羧酸

环丙基萘啶羧酸性质、用途与生产工艺

用途 

生产方法 

96568-07-9

100361-18-0

以7-氯-1-环丙基-6-氟-4-氧代-1,4-二氢-1,8-萘啶-3-羧酸乙酯（0.1g，0.32mmol）为原料，将其溶解于THF（5ml）中。向该溶液中加入浓HCl（45μL，0.7mmol）。将反应混合物加热至回流状态，持续反应2小时。通过薄层色谱（TLC）监测反应进度，确认反应完成后，将反应混合物冷却至室温。过滤收集析出的固体，得到目标产物7-氯-1-环丙基-6-氟-1,4-二氢-4-氧代-1,8-萘啶-3-羧酸，产量为70mg，收率为78%。

参考文献：

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 7, p. 2428 - 2433

[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 25, p. 5564 - 5575

[3] Patent: WO2005/40164, 2005, A1. Location in patent: Page/Page column 10-12

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