16Α-甲基孕甾-1,4,9(11)-三烯-17Α,21-二醇-3,20-二酮-21-醋酸酯

16Α-甲基孕甾-1,4,9(11)-三烯-17Α,21-二醇-3,20-二酮-21-醋酸酯性质、用途与生产工艺

化学性质 

结晶。熔点208℃。

用途 

地塞米松醋酸酯的中间体。

生产方法 

可用3β-羟基孕甾-5,16-二烯-20-酮-3-醋酸酯（即妊娠双烯醇酮醋酸酯）经（16-位双键亚硝基甲基脲）加成并消除，生成3β-羟基-16β-甲基孕甾-5,16-二烯-20-酮，然后[16（17）-位]环氧化、乙酰化并环氧基开环（形成17α-羟基及15-位双键）、进而（15-位双键）催化氢化、水解（脱3-位乙酰基）、（3-位羟基）氧化（双键转至4-位）、（21-位）碘化、（21-位碘以乙酰氧基）置换、生物氧化（引入11-位羟基）（11-位羟基）磺酰化并消除[形成9（11）-双键]制得该品。

16Α-甲基孕甾-1,4,9(11)-三烯-17Α,21-二醇-3,20-二酮-21-醋酸酯 上下游产品信息

上游原料

下游产品

16Α-甲基孕甾-1,4,9(11)-三烯-17Α,21-二醇-3,20-二酮-21-醋酸酯 生产厂家

 

10106-41-9, 16Α-甲基孕甾-1,4,9(11)-三烯-17Α,21-二醇-3,20-二酮-21-醋酸酯 相关搜索:

• Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• 原料药
• 杂质-地塞米松杂质
• 杂质-醋酸地塞米松杂质
• 杂质对照品
• 地塞米松杂质
• 标准品
• 16Α-甲基孕甾-1,4,9(11)-三烯-17Α,21-二醇-3,20-二酮-21-醋酸酯
• 2-(((8S,10S,13S,14S,16R,17R)-17-羟基-10,13,16-三甲基-3-氧代-6,7,8,10,12,13,14,15,16 ,17-十氢-3H-环戊[a]菲蒽-17-基)-2-氧代乙酸乙酯(地塞米松杂质)
• 醋酸地塞米松杂质8
• 2-((8S,10S,13S,14S,16R,17R)-17-羟基-10,13,16-三甲基-3-氧代-6,7,8,10,12,13,14,15,16,17-十氢-3H-环戊[A]菲-17-基)-2-氧代乙酸乙酯
• 地塞米松杂质8(地塞米松EP杂质H)
• 醋酸地塞米松杂质8(醋酸地塞米松EP杂质H)
• 醋酸地塞米松杂质H
• 地塞米松EP杂质H(醋酸地塞米松EP杂质H)
• 地塞米松杂质H
• 21-二羟基-16&ALPHA-甲基孕甾-1,4,9(11)-三烯-3,20-二酮-21-醋酸酯
• 地塞米松磷酸钠杂质H
• 醋酸地塞米松EP杂质H
• 地塞米松杂质杂质H
• 地塞米松杂质31
• 地塞米松杂质H(EP)
• 16Α-甲基孕甾-1,4,9(11)-三烯-17Α,21-二醇-3,20-二酮-21-醋酸酯
• 地塞米松EP杂质H
• 10106-41-9
• 17,21-Dihydroxy-16a-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate
• (16α)-17-Hydroxy-16-methyl-3,20-dioxopregna-1,4,9(11)-trien-21-yl acetate
• 2-((8S,10S,13S,14S,16R,17R)-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate (Dexamethasone Impurity）
• Dexamethasone Acetate Impurity 8
• (16α)-21-(Acetyloxy)-17-hydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione
• 17,21-Dihydroxy-16Alpha-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate
• Dexamethasone EP Impurity H(Dexamethasone Acetate EP Impurity H)
• Dexamethasone Acetate Impurity H
• "17,21-Dihydroxy-16-β-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate"
• Pregna-1,4,9(11)-triene-3,20-dione,21-(acetyloxy)-17-hydroxy-16-methyl-, (16a)-
• 17-hydroxy-16α-methyl-3,20-dioxopregna-1,4,9(11)-trien-21-yl acetate
• 17α, 21-dihydroxy-16α-methyl-1, 4 ,9(11)-pregnatriene-3, 20-dione 21-acetate
• 17,21-Dihydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione 21-Acetate
• Pregna-1,4,9(11)-triene-3,20-dione, 21-(acetyloxy)-17-hydroxy-16-methyl-, (16α)-
• Dexamethasone Acetate Impurity 8（Dexamethasone Acetate EP Impurity H）
• Dexamethasone EP Imp H
• Dexamethasone impurity 2/Dexamethasone EP Impurity H
• 2-((8S,10S,13S,14S,16R,17R)-17
• (16α)-17-Hydroxy-16-methyl-3,20-dioxopregna-1,4,9(11)-trien-21-yl acetate
• 17-alpha,21-Dihydroxy-16-a-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate
• Dexamethasone Impurity 8(Dexamethasone EP Impurity H)
• Dexamethasone Acetate EP Impurity H
• Dexamethasone impurity H
• 2-((10S,13S,14S,16R,17R)-17-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
• Pregna-1,4,9(11)-triene-3,20-dione, 17,21-dihydroxy-16.alpha.-methyl-, 21-acetate
• 17-alpha,21-dihydroxy-16-alpha-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate
• Pregnatriene acetate
• 21-Acetoxy-17-hydroxy-16α-methylpregna-1,4,9(11)-triene-3,20-dione
• 17-HYDROXY-16-ALPHA-METHYL-3,20-DIOXOPREGNA-1,4,9(11)-TRIEN-21-YL ACETATE
• 21-Acetyloxy-17-hydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione
• 17,21-Dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate