MCTR2
- CAS No.
- 1784701-62-7
- Chemical Name:
- MCTR2
- Synonyms
- MCTR2;Glycine, S-[(1R,2E,4E,6Z,9Z)-12-carboxy-1-[(1S,3Z,6Z)-1-hydroxy-3,6-nonadien-1-yl]-2,4,6,9-dodecatetraen-1-yl]-L-cysteinyl-;S-?[(1R,?2E,?4E,?6Z,?9Z)?-?12-Carboxy-?1-?[(1S,?3Z,?6Z)?-?1-?hydroxy-?3,?6-?nonadien-?1-?yl]?-?2,?4,?6,?9-?dodecatetraen-?1-?yl]?-?L-?cysteinyl-glycine
- CBNumber:
- CB04666600
- Molecular Formula:
- C27H40N2O6S
- Molecular Weight:
- 520.68
- MDL Number:
- MOL File:
- 1784701-62-7.mol
| Product description | Number | Pack Size | Price |
| MCTR2 ≥97% | 17008 | 10μg | $153 |
| MCTR2 ≥97% | 17008 | 25μg | $362 |
| MCTR2 ≥97% | 17008 | 50μg | $684 |
| MCTR2 ≥97% | 17008 | 100μg | $1199 |
| S-[(1R,2E,4E,6Z,9Z)-12-Carboxy-1-[(1S,3Z,6Z)-1-hydroxy-3,6-nonadien-1-yl]-2,4,6,9-dodecatetraen-1-yl]-L-cysteinyl-glycine | C178710 | 10g | $125 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
MCTR2 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17008 | MCTR2 ≥97% | 1784701-62-7 | 10μg | $153 | 2024-03-01 | Buy |
| Cayman Chemical | 17008 | MCTR2 ≥97% | 1784701-62-7 | 25μg | $362 | 2024-03-01 | Buy |
| Cayman Chemical | 17008 | MCTR2 ≥97% | 1784701-62-7 | 50μg | $684 | 2024-03-01 | Buy |
| Cayman Chemical | 17008 | MCTR2 ≥97% | 1784701-62-7 | 100μg | $1199 | 2024-03-01 | Buy |
| TRC | C178710 | S-[(1R,2E,4E,6Z,9Z)-12-Carboxy-1-[(1S,3Z,6Z)-1-hydroxy-3,6-nonadien-1-yl]-2,4,6,9-dodecatetraen-1-yl]-L-cysteinyl-glycine | 1784701-62-7 | 10g | $125 | 2021-12-16 | Buy |
MCTR2 Chemical Properties,Uses,Production
Description
Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ) in macrophages at the site of inflammation. DHA is oxidized to maresin 1 (MaR1; ), which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD2 and PGF2α in the exudate.
Uses
S-?[(1R,?2E,?4E,?6Z,?9Z)?-?12-Carboxy-?1-?[(1S,?3Z,?6Z)?-?1-?hydroxy-?3,?6-?nonadien-?1-?yl]?-?2,?4,?6,?9-?dodecatetraen-?1-?yl]?-?L-?cysteinyl-glycine is synthesized from omega-3 essential fatty acids and utilized by macrophages in molecular pathways related to tissue regeneration and inflammation.
Definition
ChEBI: (13R)-S-cysteinylglycinyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid is a docosanoid that is (14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid in which a cysteinylglycinyl group is attached at position 13R via a sulfide linkage. It has a role as a human metabolite. It is a docosanoid, an organic sulfide, a secondary alcohol, a dicarboxylic acid and a dipeptide. It is a conjugate acid of a (13R)-glycinylcystein-S-yl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate(1-).
References
[1] SERHAN C N. Pro-resolving lipid mediators are leads for resolution physiology[J]. Nature, 2014, 510 7503: 92-101. DOI: 10.1038/nature13479
[2] J. DALLI. Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3[J]. PLoS ONE, 2016, 11 1. DOI: 10.1371/journal.pone.0149319
[3] J. DALLI. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages[J]. Proceedings of the National Academy of Sciences, 2016, 26 1: 12232-12237. DOI: 10.1073/pnas.1607003113
MCTR2 Preparation Products And Raw materials
Raw materials
Preparation Products
MCTR2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32436 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7982 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29343 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
