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(R)-N-BOC-2-methylproline

(R)-N-BOC-2-methylproline Structure
(R)-N-BOC-2-methylproline structure
CAS No.
166170-15-6
Chemical Name:
(R)-N-BOC-2-methylproline
Synonyms
(R)-1-(tert-Butoxycarbonyl)-2-Methylpyrrolidine-2-carboxylic acid;EOS-61195;Boc-α-Me-D-Pro-OH;Boc-a-Me-D-Pro-OH;Boc-alpha-Me-D-Pro-OH;1-Boc-2-Methyl-D-proline;N-Boc-2-methyl-D-proline;(R)-N-BOC-2-methylproline;(R)-N-BOC-Α-METHYLPROLINE;(R)-N-Boc-a-Methylproline
CBNumber:
CB11563617
Molecular Formula:
C11H19NO4
Molecular Weight:
229.27
MDL Number:
MFCD06797554
MOL File:
166170-15-6.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:45
Product description Number Pack Size Price
(R)-1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylicAcid T135698 50mg $60
Boc-α-Me-D-Pro-OH 181676 1g $726
(R)-1-(Boc)-2-Methylpyrrolidine-2-carboxylic acid 97+% ee AS55360-2R 100g $746
Boc-α-Me-D-Pro-OH 181676 5g $1778
(R)-1-(Boc)-2-Methylpyrrolidine-2-carboxylic acid 97+% ee AS55360-2R 1g $34
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(R)-N-BOC-2-methylproline Properties

Melting point 127-129℃
Boiling point 337.8±35.0 °C(Predicted)
Density 1.160
storage temp. 2-8°C
pka 4.20±0.20(Predicted)
Appearance Off-white to brown Solid
InChI InChI=1S/C11H19NO4/c1-10(2,3)16-9(15)12-7-5-6-11(12,4)8(13)14/h5-7H2,1-4H3,(H,13,14)/t11-/m1/s1
InChIKey YQXRKJHVAUKXRN-LLVKDONJSA-N
SMILES N1(C(OC(C)(C)C)=O)CCC[C@]1(C)C(O)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

(R)-N-BOC-2-methylproline price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC T135698 (R)-1-(tert-Butoxycarbonyl)-2-methylpyrrolidine-2-carboxylicAcid 166170-15-6 50mg $60 2021-12-16 Buy
ChemPep 181676 Boc-α-Me-D-Pro-OH 166170-15-6 1g $726 2021-12-16 Buy
Activate Scientific AS55360-2R (R)-1-(Boc)-2-Methylpyrrolidine-2-carboxylic acid 97+% ee 166170-15-6 100g $746 2021-12-16 Buy
ChemPep 181676 Boc-α-Me-D-Pro-OH 166170-15-6 5g $1778 2021-12-16 Buy
Activate Scientific AS55360-2R (R)-1-(Boc)-2-Methylpyrrolidine-2-carboxylic acid 97+% ee 166170-15-6 1g $34 2021-12-16 Buy
Product number Packaging Price Buy
T135698 50mg $60 Buy
181676 1g $726 Buy
AS55360-2R 100g $746 Buy
181676 5g $1778 Buy
AS55360-2R 1g $34 Buy

(R)-N-BOC-2-methylproline Chemical Properties,Uses,Production

Synthesis

2-benzyl 1-(tert-butyl) (R)-2-methylpyrrolidine-1,2-dicarboxylate

912445-03-5

(R)-N-BOC-2-methylproline

166170-15-6

General procedure for the synthesis of (R)-1-(tert-butoxycarbonyl)-2-methylpyrrolidine-2-carboxylic acid from the compound (CAS: 912445-03-5): Step 74D: Synthesis of (R)-2-methylpyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester A 5% palladium-carbon catalyst (2.56 g) was added to the pressure reactor and the reactor was purged with nitrogen. The Example 74C product (α60wt% isopropyl acetate solution, 83.1 g) and denatured ethanol (335 g) were then added. The reactor was pressurized with hydrogen (40 psig) and the hydrogenolysis reaction was carried out while controlling the reaction temperature to not exceed 40°C. Upon completion of the reaction, the catalyst was removed by filtration to give a product with a measured yield of 97% and an enantiomeric excess (ee) of 93.9%. Post-treatment step: the solvent was removed by distillation under vacuum and solvent replacement was carried out with isopropyl acetate (240 g). This was followed by the addition of heptane (200 g) for further replacement, then additional heptane (500 g) was added and the mixture was heated to reflux until all solids were completely dissolved. After cooling the solution to 20°C, the solid product was collected by filtration, washed with heptane (80 g) and dried to give 54.8 g of Example 74D product in 88% yield. Product characterization: 1H NMR (400 MHz, CDCl3, rotary isomer mixture) δ ppm 1.42 (s) and 1.47 (s), (9H); 1.52 (s) and 1.61 (s) (2H); 1.73-2.05 (m, 3H); 2.19-2.38 (m) and 2.46-2.67 (m) (1H); 3.26- 3.71 (m, 2H).

References

[1] Patent: US2006/229289, 2006, A1. Location in patent: Page/Page column 29-30

(R)-N-BOC-2-methylproline Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 2-benzyl 1-(tert-butyl) (R)-2-methylpyrrolidine-1,2-dicarboxylate H-ALPHA-ME-D-PRO-OH Ethanol Hydrogen
Isopropyl acetate

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Preparation Products

(R)-N-BOC-2-methylproline Suppliers

Global( 127)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20128 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29831 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 8497 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
GL Biochem (Shanghai) Ltd. 		+86-021-61263370 +86-18901917034 CHINA 3904 58
Hangzhou Huarong Pharm Co., Ltd. 		571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3148 58
Unibest Industrial Co.,Ltd. 		+86-0574-27855777 +8618758850676 info@unibestcn.com China 270 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
BOC Sciences 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
GL Biochem (Shanghai) Ltd. 		58
Hangzhou Huarong Pharm Co., Ltd. 		58
Unibest Industrial Co.,Ltd. 		58
Nextpeptide Inc 		58

View Lastest Price from (R)-N-BOC-2-methylproline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-N-BOC-2-methylproline pictures 2025-09-25 (R)-N-BOC-2-methylproline
166170-15-6
 US $35.00-1.20 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
(R)-N-BOC-2-methylproline pictures 2025-04-04 (R)-N-BOC-2-methylproline
166170-15-6
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
(R)-N-BOC-2-methylproline pictures 2019-07-06 (R)-N-BOC-2-methylproline
166170-15-6
 US $1.00 / KG 1KG 99% Customized Career Henan Chemical Co

(R)-N-BOC-2-methylproline Spectrum

(R)-N-BOC-2-methylproline(166170-15-6)1HNMR

166170-15-6((R)-N-BOC-2-methylproline)Related Search:

(2R)-1-[(tert-butoxy)carbonyl]-2-methylazetidine-2-carboxylic acid (R)-1-(Benzyloxycarbonyl)-2-Methylpyrrolidine-2-carboxylic acid (R)-1-(tert-butoxycarbonyl)-2-(hydroxymethyl)pyrrolidine-2-carboxylic acid α-Me-D-Phe(3-NO2)-OH·H2O (S)-2-Methylproline
α-Me-Phe(2-NO2)-OH·H2O α-Me-Phe(3-NO2)-OH·H2O α-Me-Phe(4-Ph)-OH·H2O N-BOC-ALPHA-METHYL-L-PROLINE α-Me-D-Phe(2-NO2)-OH·H2O
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(R)-N-BOC-2-methylproline 1-(tert-butoxycarbonyl)-2-methyl-D-proline(SALTDATA: FREE) 1,2-Pyrrolidinedicarboxylic acid, 2-methyl-, 1-(1,1-dimethylethyl) ester, (2R)- (2R)-2-Methyl-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester 1-Boc-2-Methyl-D-proline (R)-1-Boc-2-Methyl-proline (R)-N-BOC-Α-METHYLPROLINE Boc-α-Me-D-Pro-OH (R)-1-(tert-Butoxycarbonyl)-2-Methylpyrrolidine-2-carboxylic acid (2R)-1-[(tert-butoxy)carbonyl]-2-methylpyrrolidine-2-carboxylic acid Boc-alpha-Me-D-Pro-OH (R)-N-BOC-alpha-METHYLPROLINE (2R)-2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid EOS-61195 (Tert-Butoxy)Carbonyl Alpha-Methyl-D-Pro-OH Boc-a-Me-D-Pro-OH N-Boc-2-methyl-D-proline (2R)-2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrroli (R)-N-Boc-a-Methylproline 1-(tert-butoxycarbonyl)-2-methyl-D-proline 166170-15-6 α-Methyl Amino Acids