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ChemicalBook >> CAS DataBase List >>(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Structure
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol structure
CAS No.
779353-01-4
Chemical Name:
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
Synonyms
Dinaciclib;Sch 727965;CS-213;PS-095760;Dinaciclib, >=98%;SCH 727965DINACICLIB;Dinaciclib (SCH 727965);Dinaciclib, 10 mM in DMSO;Dinaciclib (SCH727965), ≥98%;SCH 727965; SCH727965; SCH-727965
CBNumber:
CB22554279
Molecular Formula:
C21H28N6O2
Molecular Weight:
396.49
MDL Number:
MFCD16037702
MOL File:
779353-01-4.mol
MSDS File:
SDS
Last updated:2025-12-15 14:23:52
Product description Number Pack Size Price
Dinaciclib ≥98% 14707 5mg $93
Dinaciclib ≥98% 14707 10mg $176
Dinaciclib ≥98% 14707 25mg $412
Dinaciclib ≥98%(HPLC) 7336 10 $139
Dinaciclib 163876 5mg $389
More product size
Request For Quotation

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Properties

Melting point >78oC (dec.)
Density 1.33
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Chloroform (Slightly), Methanol (Slightly)
pka 15.15±0.10(Predicted)
form Solid
color White to Light Beige
Stability Hygroscopic
InChIKey PIMQWRZWLQKKBJ-SFHVURJKSA-N
SMILES N1(C2C=C(NCC3C=CC=[N+]([O-])C=3)N3N=CC(CC)=C3N=2)CCCC[C@H]1CCO
CAS DataBase Reference 779353-01-4
FDA UNII 4V8ECV0NBQ
NCI Dictionary of Cancer Terms dinaciclib
NCI Drug Dictionary dinaciclib
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS08,GHS07
Signal word  Danger
Hazard statements  H319-H340-H372-H315
Precautionary statements  P260-P264-P270-P314-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
NFPA 704
0
2 0

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14707 Dinaciclib ≥98% 779353-01-4 5mg $93 2024-03-01 Buy
Cayman Chemical 14707 Dinaciclib ≥98% 779353-01-4 10mg $176 2024-03-01 Buy
Cayman Chemical 14707 Dinaciclib ≥98% 779353-01-4 25mg $412 2024-03-01 Buy
Tocris 7336 Dinaciclib ≥98%(HPLC) 779353-01-4 10 $139 2021-12-16 Buy
Usbiological 163876 Dinaciclib 779353-01-4 5mg $389 2021-12-16 Buy
Product number Packaging Price Buy
14707 5mg $93 Buy
14707 10mg $176 Buy
14707 25mg $412 Buy
7336 10 $139 Buy
163876 5mg $389 Buy

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Chemical Properties,Uses,Production

Uses

Dinaciclib is a potent and selective inhibitor of cyclin-dependent kinases which is undergoing development as oncology therapeutics.

Definition

ChEBI: 2-[(2S)-1-[3-ethyl-7-[(1-oxido-3-pyridin-1-iumyl)methylamino]-5-pyrazolo[1,5-a]pyrimidinyl]-2-piperidinyl]ethanol is a pyrazolopyrimidine.

Biological Activity

dinaciclib is a potent cyclin-dependent kinase (cdk) inhibitor with ic50s for cdk2, cdk5, cdk1 and cdk9 at 1 nm, 1 nm, 3 nm, and 4 nm, respectively. [1] it is in phase i or ii

target

CDK2

storage

Store at -20°C

References

[1]parry d., et al. (2010). dinaciclib (sch 727965), a novel and potent cyclin-dependent kinase inhibitor. mol cancer ther (9): 2344- 2353.
[2]martin, m. p., et al. (2013). cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains. acs chemical biology 8 (11): 2360–5.
[3]payton m., et al. (2006). discovery and evaluation of dual cdk1 and cdk2 inhibitors. cancer res 66: 4299-4308.

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Preparation Products And Raw materials

Raw materials

Preparation Products

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Suppliers

Global( 181)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29845 58
Changzhou PBpharmaceutical R&D Co.,Ltd 		0519-83990708 info@pbpharm.com CHINA 498 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 8025 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Changzhou PBpharmaceutical R&D Co.,Ltd 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Labnetwork lnc. 		58

View Lastest Price from (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dinaciclib pictures 2025-12-15 Dinaciclib
779353-01-4
 US $47.00-121.00 / mg 99.75% 10g TargetMol Chemicals Inc.
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol pictures 2025-06-25 (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
779353-01-4
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol pictures 2025-04-04 (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
779353-01-4
 US $0.00-0.00 / KG 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
  • Dinaciclib pictures
  • Dinaciclib
    779353-01-4
  • US $47.00-121.00 / mg
  • 99.75%
  • TargetMol Chemicals Inc.

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Spectrum

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol(779353-01-4)MS(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol(779353-01-4)1HNMR

779353-01-4((2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol)Related Search:

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PD 0332991 HCl Flavopiridol (Alvocidib) HCl Roscovitine

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(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Dinaciclib (SCH727965) 2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)- Dinaciclib, >=98% DINACICLIB (SCH727965);SCH 727965 (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol (S)-3-(((3-Ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)methy Dinaciclib (SCH727965), ≥98% CS-213 SCH 727965; SCH727965; SCH-727965 SCH 727965;SCH727965;SCH-727965;PS-095760 Dinaciclib Sch 727965 PS-095760 (S)-3-((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyriMidin-7-ylaMino)Methyl)pyridine 1-oxide SCH 727965DINACICLIB DINACICLIB(SCH-727965, PS-095760) 3-[({8-ethyl-2-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrrolo[1,2-a]pyriMidin-4-yl}aMino)Methyl]pyridin-1-iuM-1-olate Dinaciclib (SCH 727965) 2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol ISO 9001：2015 REACH inhibit,Dinaciclib,SCH727965,Inhibitor,SCH-727965,Cyclin dependent kinase,CDK,Apoptosis Dinaciclib, cyclin-dependent kinase (CDK) inhibitor Dinaciclib, 10 mM in DMSO (S)-3-[[[3-Ethyl-5-[2-(2-hydroxyethyl)-1-piperidyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]methyl]pyridine 1-Oxide 779353-01-4 C21H28N6O2 Inhibitors