ChemicalBook >> CAS DataBase List >>4-(Trifluoromethyl)-L-phenylalanine

4-(Trifluoromethyl)-L-phenylalanine

4-(Trifluoromethyl)-L-phenylalanine structure

CAS No.: 114926-38-4

Chemical Name:: 4-(Trifluoromethyl)-L-phenylalanine

Synonyms: H-PHE(4-CF 3)-OH;RARECHEM BK PT 0139;L-4-TRIFLUOROMETHYLPHE;L-4-Trifluoromethyl-phe-OH;H-L-PHE(4-TRIFLUOROMETHYL)-OH;L-4-TRIFLUOROMETHYLPHENYLALANINE;p-Trifluoromethyl-L-phenylalanine;4-(TRIFLUOROMETHYL)-L-PHENYLALANINE;L-Phenylalanine,4-(trifluoroMethyl)-;3-(4-Trifluoromethylphenyl)-L-alanine

CBNumber:: CB3193381

Molecular Formula:: C10H10F3NO2

Molecular Weight:: 233.19

MDL Number:: MFCD00044946

MOL File:: 114926-38-4.mol

MSDS File:: SDS

Last updated:2025-09-09 10:27:52

Product description	Number	Pack Size	Price
4-(Trifluoromethyl)-L-phenylalanine	T897038	50mg	$45
p-Trifluoromethyl-L-phenylalanine	241151	250mg	$233
4-(TRIFLUOROMETHYL)-L-PHENYL ALANINE 95.00%	AAA0000761	5G	$1472.63
-Trifluoromethyl-L-phenylalanine ≥ 99% (HPLC)	07388	25G	$2410
4-(Trifluoromethyl)-L-phenylalanine 97%	PC01528	1g	$87

Request For Quotation

4-(Trifluoromethyl)-L-phenylalanine Properties

Boiling point	311.5±42.0 °C(Predicted)
Density	1.364±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
pka	2.15±0.10(Predicted)
form	solid
color	White to yellow
optical activity	-16.23°(C=0.01g/ml MEOH)
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C10H10F3NO2/c11-10(12,13)7-3-1-6(2-4-7)5-8(14)9(15)16/h1-4,8H,5,14H2,(H,15,16)/t8-/m0/s1
InChIKey	CRFFPDBJLGAGQL-QMMMGPOBSA-N
SMILES	C(O)(=O)[C@H](CC1=CC=C(C(F)(F)F)C=C1)N
CAS DataBase Reference	114926-38-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280-P271

Safety Statements

22-24/25

WGK Germany

HS Code

2922498590

NFPA 704

	1
0		0

4-(Trifluoromethyl)-L-phenylalanine price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	T897038	4-(Trifluoromethyl)-L-phenylalanine	114926-38-4	50mg	$45	2021-12-16	Buy
Usbiological	241151	p-Trifluoromethyl-L-phenylalanine	114926-38-4	250mg	$233	2021-12-16	Buy
American Custom Chemicals Corporation	AAA0000761	4-(TRIFLUOROMETHYL)-L-PHENYL ALANINE 95.00%	114926-38-4	5G	$1472.63	2021-12-16	Buy
Chem-Impex	07388	-Trifluoromethyl-L-phenylalanine ≥ 99% (HPLC)	114926-38-4	25G	$2410	2021-12-16	Buy
Apolloscientific	PC01528	4-(Trifluoromethyl)-L-phenylalanine 97%	114926-38-4	1g	$87	2021-12-16	Buy

Product number	Packaging	Price	Buy
T897038	50mg	$45	Buy
241151	250mg	$233	Buy
AAA0000761	5G	$1472.63	Buy
07388	25G	$2410	Buy
PC01528	1g	$87	Buy

4-(Trifluoromethyl)-L-phenylalanine Chemical Properties,Uses,Production

Uses

4-fluoro-l-phenylalanine (fF), or 4-trifluoromethyl-l-phenylalanine were introduced inside the chain of peptides to enhances their antimicrobial activity..

Synthesis

diethyl 2-(acetylamino)-2-[4-(trifluoromethyl)benzyl]malonate

114872-59-2

82337-58-4

3832-75-5

Step 2: Diethyl 2-acetamido-2-(4-(trifluoromethyl)benzyl)malonate (LXII, theoretical amount 0.125 mol) was dissolved in acetone (400 mL) and 2 M aqueous NaOH solution (400 mL) was added. The reaction mixture was refluxed overnight and subsequently concentrated under reduced pressure to remove the solvent. The residue was dissolved in water and washed with hexane (3 x 400 mL). The aqueous phase was adjusted to pH=1 with acid and the precipitate was collected by filtration to afford 2-acetamido-3-(4-(trifluoromethyl)phenyl)propionic acid (LXIII) as a white solid (25.8 g, 93.7 mmol, 75% overall yield in two steps).

References

[1] Patent: WO2012/109164, 2012, A1. Location in patent: Page/Page column 53-54

4-(Trifluoromethyl)-L-phenylalanine Preparation Products And Raw materials

Raw materials

diethyl 2-(acetylamino)-2-[4-(trifluoromethyl)benzyl]malonate Acetone Sodium hydroxide

Preparation Products

4-(Trifluoromethyl)-L-phenylalanine Suppliers

Global( 142)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19908	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
GenicBio Limited	+86-21-37621270	service@genicbio.com	CHINA	991	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
GL Biochem (Shanghai) Ltd.	+86-021-61263370 +86-18901917034		CHINA	3904	58

Supplier	Advantage
Nextpeptide Inc	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
GenicBio Limited	58
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
GL Biochem (Shanghai) Ltd.	58

View Lastest Price from 4-(Trifluoromethyl)-L-phenylalanine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-10-13	4-(Trifluoromethyl)phenylalanine 114926-38-4	US $2.20-8.80 / kg	1kg	99%min	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2019-09-02	4-(Trifluoromethyl)-L-phenylalanine 114926-38-4	US $7.00 / KG	1KG	99%	JD 354	Career Henan Chemical Co

4-(Trifluoromethyl)phenylalanine
114926-38-4
US $2.20-8.80 / kg
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

4-(Trifluoromethyl)-L-phenylalanine
114926-38-4
US $7.00 / KG
99%
Career Henan Chemical Co

4-(Trifluoromethyl)-L-phenylalanine Spectrum

4-(Trifluoromethyl)-L-phenylalanine(114926-38-4)¹HNMR

114926-38-4(4-(Trifluoromethyl)-L-phenylalanine)Related Search:

Propionic acid N-(tert-Butoxycarbonyl)-L-phenylalanine 6-Aminocaproic acid 3-(Trifluoromethyl)benzaldehyde 3-（trifluoromethyl) Cinnamaldehyde

Phenyl salicylate 4-Nitro-3-phenyl-L-alanine Diphenyl ether ALTRENOGEST (Trifluoromethyl)trimethylsilane

PHENYL VALERATE Trifluoromethanesulfonic anhydride Phenprobamate D-4-TRIFLUOROMETHYLPHENYLALANINE L-Phenylalanine

Glycine PHENYL RESIN Fluorenylmethoxycarbonyl-L-4-trifluoromethylphenylalanine,FMOC-L-4-TRIFLUOROMETHYLPHENYLALANINE,FMOC-4-(Trifluoromethyl)-L-phenylalanine

1of4

L-4-TRIFLUOROMETHYLPHE 4-(TRIFLUOROMETHYL)-L-PHENYLALANINE L-4-TRIFLUOROMETHYLPHENYLALANINE L-3-[4-(TRIFLUOROMETHYL)PHENYL]ALANINE H-L-PHE(4-TRIFLUOROMETHYL)-OH H-PHE(4-CF 3)-OH (S)-2-AMINO-3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID RARECHEM BK PT 0139 (2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propanoic acid 3-(4-Trifluoromethylphenyl)-L-alanine L-4-Trifluoromethyl-phe-OH REF DUPL: 4-Trifluoromethyl-L-Phenylalanine L-Phenylalanine,4-(trifluoroMethyl)- p-Trifluoromethyl-L-phenylalanine 4-(Trifluoromethyl)-L-phenylalanine, >=98% 4-Trifluoromethyl-L-phenylalanine,95% 4-(Trifluoromethyl)-L-phenylalanine USP/EP/BP 114926-38-4 Phenylalanine Derivatives Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives a-amino Amino Acids