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bruceine D

bruceine D structure

CAS No.: 21499-66-1

Chemical Name:: bruceine D

Synonyms: BRUCEIND;Nsc318801;Bruceine D, 10 mM in DMSO;Parasite,Notch,Apoptosis,Bruceine D,Inhibitor,inhibit;Picras-3-ene-2,16-dione, 13,20-epoxy-1,11,12,14,15-pentahydroxy-, (1β,11β,12α,15β)-;(1beta,11beta,12alpha,15beta)-13,20-Epoxy-1,11,12,14,15-pentahydroxypicras-3-ene-2,16-dione;(1R,2R,3R,6R,8S,12S,13S,14R,15R,16S,17R)-2,3,12,15,16-pentahydroxy-9,13,17-trimethyl-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-4,11-dione;(1R,2S,3R,3aR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-Pentahydroxy-3,8,11a-trimethyl-2,3,3a,4,7,7a,11,11a-octahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromen-5,10(6aH,11bH)-dione;(1R,2S,3R,3aR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-3,8,11a-trimethyl-2,3,3a,4,7,7a,11,11a-octahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH,11bH)-dione;(1R,2S,3R,3AR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-3,8,11a-trimethyl-1,2,3,3a,4,7,7a,11,11a,11b-decahydro-5H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH)-dione

CBNumber:: CB41318443

Molecular Formula:: C20H26O9

Molecular Weight:: 410.42

MDL Number:: MFCD00221753

MOL File:: 21499-66-1.mol

Last updated:2026-03-04 10:44:01

Product description	Number	Pack Size	Price
Bruceine D	FB145214	2mg	$90
BruceineD 95.75%	CS-0022968	5mg	$158
Bruceine D	FB145214	5mg	$180
BruceineD	0936AB	5mg	$220
BruceineD 95.75%	CS-0022968	10mg	$269
More product size

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bruceine D Properties

Melting point	294-295℃
Boiling point	661.3±55.0 °C(Predicted)
Density	1.60
storage temp.	2-8°C
solubility	DMSO: 100 mg/mL (243.65 mM)
pka	11.55±0.70(Predicted)
form	Solid
color	White to off-white
InChIKey	JBDMZGKDLMGOFR-SOKPEVJONA-N
SMILES	[C@@]123CO[C@@]4([C@@H](O)[C@H](O)C1[C@@]1(C)[C@H](O)C(C=C(C)[C@]1([H])C[C@@]2([H])OC(=O)[C@H](O)[C@]34O)=O)C \|&1:0,3,4,6,9,11,17,20,25,27,r\|

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H227
Precautionary statements	P501-P210-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313-P403+P235

bruceine D price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth Carbosynth	FB145214	Bruceine D	21499-66-1	2mg	$90	2021-12-16	Buy
ChemScene	CS-0022968	BruceineD 95.75%	21499-66-1	5mg	$158	2021-12-16	Buy
Biosynth Carbosynth	FB145214	Bruceine D	21499-66-1	5mg	$180	2021-12-16	Buy
AK Scientific	0936AB	BruceineD	21499-66-1	5mg	$220	2021-12-16	Buy
ChemScene	CS-0022968	BruceineD 95.75%	21499-66-1	10mg	$269	2021-12-16	Buy

Product number	Packaging	Price	Buy
FB145214	2mg	$90	Buy
CS-0022968	5mg	$158	Buy
FB145214	5mg	$180	Buy
0936AB	5mg	$220	Buy
CS-0022968	10mg	$269	Buy

bruceine D Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the fruit of Brucea javanica.

Uses

Bruceine D is a Notch inhibitor with anti-cancer activity and induces apoptosis in several human cancer cells. Bruceine D is an effective botanical insect antifeedant with outstanding systemic properties, causing potent pest growth inhibitory activity[1][2]. Bruceine D has strong anthelmintic activity against D. intermedius with an EC50 value of 0.57 mg/L[3].

Definition

ChEBI: A quassinoid that is 13,20-epoxypicras-3-ene substituted by hydroxy groups at positions 1, 11, 12, 14 and 15 and oxo groups at positions 2 and 16. Isolated from the ethanol extract of the stem of Brucea mollis, it exhibits cytotoxic activity.

References

[1] Mao G,et al. Bruceine D Isolated from Brucea Javanica (L.) Merr. as a Systemic Feeding Deterrent for Three Major Lepidopteran Pests. J Agric Food Chem. 2019 Apr 17;67(15):4232-4239. DOI:10.1021/acs.jafc.8b06511
[2] Cheng Z, et al. Bruceine D inhibits hepatocellular carcinoma growth by targeting β-catenin/jagged1 pathways. Cancer Lett. 2017 Sep 10;403:195-205. DOI:10.1016/j.canlet.2017.06.014
[3] Yong Wang, et al. In vivo anthelmintic activity of bruceine A and bruceine D from Brucea javanica against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Vet Parasitol. 2011 Apr 19;177(1-2):127-33. DOI:10.1016/j.vetpar.2010.11.040

bruceine D Preparation Products And Raw materials

Raw materials

Preparation Products

bruceine D Suppliers

Global( 119)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
Chengdu Greenpure Biopharma CO.,Ltd	18283602253; +8618283602253	jancyzheng@gcgreenpure.com	China	954	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	3751	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10236	58
Aktin Chemicals, Inc.	028-85159085	info@aktinchem.com	CHINA	1025	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
Chengdu Greenpure Biopharma CO.,Ltd	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
BOC Sciences	58
Shanghai Standard Technology Co., Ltd.	58
career henan chemical co	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
Hubei Ipure Biology Co., Ltd	58
Aktin Chemicals, Inc.	58

View Lastest Price from bruceine D manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-03	Bruceine D 21499-66-1	US $41.00-128.00 / mg		99.99%	10g	TargetMol Chemicals Inc.
2023-02-24	Bruceine D 21499-66-1	US $0.00 / mg	20mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.
2020-01-10	Bruceine D 21499-66-1	US $9.80 / KG	1KG	≥98%	20 tons	Career Henan Chemical Co

Bruceine D
21499-66-1
US $41.00-128.00 / mg
99.99%
TargetMol Chemicals Inc.

Bruceine D
21499-66-1
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

Bruceine D
21499-66-1
US $9.80 / KG
≥98%
Career Henan Chemical Co

bruceine D Spectrum

bruceine D(21499-66-1)¹HNMR

21499-66-1(bruceine D)Related Search:

bruceine A brusatol (-)-13,20-Epoxy-1β,11β,12α,14,15β,21-hexahydroxypicrasa-3-ene-2,16-dione yadanziolide A bruceine B

YADANZIOLIDE-C (+)-13,20-Epoxy-1β,6α,11β,12α,14,15β,21-heptahydroxypicrasa-3-ene-2,16-dione YADANZIOSIDE-L (-)-DIHYDROCARVYL ACETATE (+)-Isobutyl D-lactate

delta-Dodecalactone Undecanolactone (R)-BETA-HYDROXY-BETA-METHYL-DELTA-VALEROLACTONE Lactic acid isoamyl ester delta-Nonalactone

DL-LEUCIC ACID 5-Hydroxyoctanoic acid lactone 2-ISOBUTYL-4-HYDROXY-4-METHYLTETRAHYDROPYRAN

1of4

BRUCEIND Nsc318801 (1beta,11beta,12alpha,15beta)-13,20-Epoxy-1,11,12,14,15-pentahydroxypicras-3-ene-2,16-dione Picras-3-ene-2,16-dione, 13,20-epoxy-1,11,12,14,15-pentahydroxy-, (1β,11β,12α,15β)- Parasite,Notch,Apoptosis,Bruceine D,Inhibitor,inhibit (1R,2S,3R,3aR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-3,8,11a-trimethyl-2,3,3a,4,7,7a,11,11a-octahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH,11bH)-dione (1R,2S,3R,3AR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-pentahydroxy-3,8,11a-trimethyl-1,2,3,3a,4,7,7a,11,11a,11b-decahydro-5H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH)-dione Bruceine D, 10 mM in DMSO (1R,2R,3R,6R,8S,12S,13S,14R,15R,16S,17R)-2,3,12,15,16-pentahydroxy-9,13,17-trimethyl-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-4,11-dione (1R,2S,3R,3aR,3a1R,4R,6aR,7aS,11S,11aS,11bR)-1,2,3a,4,11-Pentahydroxy-3,8,11a-trimethyl-2,3,3a,4,7,7a,11,11a-octahydro-1H-3,3a1-(epoxymethano)dibenzo[de,g]chromen-5,10(6aH,11bH)-dione 21499-66-1