ChemicalBook >> CAS DataBase List >>(S)-1-Boc-3-hydroxypiperidine
(S)-1-Boc-3-hydroxypiperidine
- CAS No.
- 143900-44-1
- Chemical Name:
- (S)-1-Boc-3-hydroxypiperidine
- Synonyms
- tert-butyl (S)-3-hydroxypiperidine-1-carboxylate;(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Ibrutinib Interm 0441;CAS:143900-44-1;1,1-DiMethylethy;(S)-BOC-piperidinol;Ilutinib impurity 7;(S)-1-BOC-3-PIPERIDINOL;（S）-N-BOC-3-piperidinol;(S)-1-BOC-Piperidin-3-ol
- CBNumber:
- CB6197360
- Molecular Formula:
- C10H19NO3
- Molecular Weight:
- 201.26
- MDL Number:
- MFCD06659041
- MOL File:
- 143900-44-1.mol
- MSDS File:
- SDS
Last updated:2025-04-17 18:45:41
| Product description | Number | Pack Size | Price |
| (S)-1-Boc-3-hydroxypiperidine 97% | 687367 | 1g | $115 |
| (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) | B4446 | 1g | $21 |
| (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) | B4446 | 5g | $64 |
| (S)-1-Boc-3-hydroxypiperidine | B656650 | 50g | $200 |
| (S)-1-Boc-3-hydroxypiperidine 97% | JK994833 | 5g | $225 |
| More product size | |||
| Melting point | 34-40 °C |
|---|---|
| Boiling point | 292.3±33.0 °C(Predicted) |
| Density | 1.107±0.06 g/cm3(Predicted) |
| Flash point | 110 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in methanol. |
| pka | 14.74±0.20(Predicted) |
| form | Powder or Crystalline Powder |
| color | White to tan |
| optical activity | [α]22/D +10.0°, c = 1 in chloroform |
| InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1 |
| InChIKey | UIJXHKXIOCDSEB-QMMMGPOBSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1 |
| CAS DataBase Reference | 143900-44-1(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
(S)-1-Boc-3-hydroxypiperidine price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 687367 | (S)-1-Boc-3-hydroxypiperidine 97% | 143900-44-1 | 1g | $115 | 2025-07-31 | Buy |
| TCI Chemical | B4446 | (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) | 143900-44-1 | 1g | $21 | 2025-07-31 | Buy |
| TCI Chemical | B4446 | (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine >98.0%(GC) | 143900-44-1 | 5g | $64 | 2025-07-31 | Buy |
| TRC | B656650 | (S)-1-Boc-3-hydroxypiperidine | 143900-44-1 | 50g | $200 | 2021-12-16 | Buy |
| Frontier Specialty Chemicals | JK994833 | (S)-1-Boc-3-hydroxypiperidine 97% | 143900-44-1 | 5g | $225 | 2021-12-16 | Buy |
(S)-1-Boc-3-hydroxypiperidine Chemical Properties,Uses,Production
Uses
(S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.
Description
(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.
Chemical Properties
White powder
Uses
A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.
Uses
(S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate.
(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 615)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SyncoZymes (Shanghai) Co., Ltd., | +8613681683526 | lchen@syncozymes.com | China | 188 | 58 |
| Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 | info@rochipharma.com | China | 246 | 58 |
| Lianhe Aigen Pharmatech Co.,Ltd. | +86-18918657159; +undefined+undefined18918657159 | sales@lianhe-aigen.com | China | 300 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1014 | 58 |
| Hebei Ganmiao New material Technology Co., LTD | +86-17332992504 | sales8@hbganmiao.com | China | 300 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21604 | 55 |
Related articles
- Uses and Preparation of (S)-1-Boc-3-hydroxypiperidine
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- Jul 11，2022
View Lastest Price from (S)-1-Boc-3-hydroxypiperidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-31 | (S)-1-Boc-3-hydroxypiperidine
143900-44-1
|
US $63.00-308.00 / g | 100g | 0.99 | 100kg | Shanghai UCHEM Inc. | |
 |
2025-12-31 | (S)-1-Boc-3-hydroxypiperidine
143900-44-1
|
US $0.00-0.00 / kg | 1kg | 99.9% | 20 tons | Hangzhou ICH Biofarm Co., Ltd | |
 |
2025-12-01 | (S)-1-Boc-3-hydroxypiperidine
143900-44-1
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- (S)-1-Boc-3-hydroxypiperidine
143900-44-1
- US $63.00-308.00 / g
- 0.99
- Shanghai UCHEM Inc.
-
- (S)-1-Boc-3-hydroxypiperidine
143900-44-1
- US $0.00-0.00 / kg
- 99.9%
- Hangzhou ICH Biofarm Co., Ltd
-
- (S)-1-Boc-3-hydroxypiperidine
143900-44-1
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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(S)-1-Boc-3-hydroxypiperidine ISO 9001：2015 REACH
Ibrutinib Interm 0441
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CAS:143900-44-1
(S)-1-Boc-3-hydroxypiperidine
(S)-1-(tert-Butoxycarbonyl)-3-carboxypiperidine
tert-butyl (S)-3-hydroxypiperidine-1-carboxylate (Intermediate of Ibrutinib)
143900-44-1
14390-44-1
14390-44-1
43900-44-1
C10H19NO3HCl
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