Isoquinoline-3-carboxylic acid
- CAS No.
- 6624-49-3
- Chemical Name:
- Isoquinoline-3-carboxylic acid
- Synonyms
- NSC 53385;AKOS BB-8838;3-ISOQUINALDIC ACID;RARECHEM AL BO 1320;3-Carboxyisoquinoline;Isoquinoline-3-carboxylicaci;ISOQUINOLINE-3-CARBOXYLIC ACID;3-ISOQUINOLINECARBOXYLIC ACID 98%;Isoquinoline-3-carboxylic acid, 98%;3-Isoquinolinecarboxylic acid (6CI,9CI)
- CBNumber:
- CB6452027
- Molecular Formula:
- C10H7NO2
- Molecular Weight:
- 173.17
- MDL Number:
- MFCD00075137
- MOL File:
- 6624-49-3.mol
| Product description | Number | Pack Size | Price |
| Isoquinoline-3-carboxylic Acid | I1246 | 1G | $136 |
| Isoquinoline-3-carboxylic Acid | I1246 | 5G | $408 |
| Isoquinoline-3-carboxylic Acid ≥98% | 19194 | 1g | $81 |
| Isoquinoline-3-carboxylic Acid ≥98% | 19194 | 5g | $356 |
| Isoquinoline-3-carboxylic Acid ≥98% | 19194 | 10g | $632 |
| More product size | |||
| Melting point | 166-167°C |
|---|---|
| Boiling point | 366.4±17.0 °C(Predicted) |
| Density | 1.339±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 20 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml |
| pka | 1.20±0.30(Predicted) |
| form | A crystalline solid |
| color | Off-white to light yellow |
| InChI | InChI=1S/C10H7NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-6H,(H,12,13) |
| InChIKey | KVMMIDQDXZOPAB-UHFFFAOYSA-N |
| SMILES | C1C2=C(C=CC=C2)C=C(C(O)=O)N=1 |
| CAS DataBase Reference | 6624-49-3(CAS DataBase Reference) |
| FDA UNII | NG3LB0ST2P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-36 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| HS Code | 2933499090 | |||||||||
| NFPA 704 |
|
Isoquinoline-3-carboxylic acid price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | I1246 | Isoquinoline-3-carboxylic Acid | 6624-49-3 | 1G | $136 | 2025-07-31 | Buy |
| TCI Chemical | I1246 | Isoquinoline-3-carboxylic Acid | 6624-49-3 | 5G | $408 | 2025-07-31 | Buy |
| Cayman Chemical | 19194 | Isoquinoline-3-carboxylic Acid ≥98% | 6624-49-3 | 1g | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 19194 | Isoquinoline-3-carboxylic Acid ≥98% | 6624-49-3 | 5g | $356 | 2024-03-01 | Buy |
| Cayman Chemical | 19194 | Isoquinoline-3-carboxylic Acid ≥98% | 6624-49-3 | 10g | $632 | 2024-03-01 | Buy |
Isoquinoline-3-carboxylic acid Chemical Properties,Uses,Production
Uses
Isoquinoline-3-carboxylic Acid is a reagent used in the synthesis of an anti-Trypanosoma agent, which acts as a minor groove binder affecting the biological activity.
Synthesis
74163-81-8
6624-49-3
At 0°C, 10.0 g (0.046 mmol) of (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid was dissolved in 200 ml of N,N-dimethylformamide and 5.0 g (0.032 mmol) of potassium permanganate (KMnO4) was slowly added over 30 min. The reaction mixture was stirred at room temperature for 100 h. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio CCl3:CH3OH = 5:1) to confirm complete consumption of (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid. Subsequently, the reaction mixture was concentrated under vacuum. The residue was washed several times with distilled water to give 8.1 g (83% yield) of isoquinoline-3-carboxylic acid as a yellow powder. The product was analyzed by ESI-MS (m/e) showing [M + H]+ peak of 174; 1H NMR (300 MHz, DMSO) δ/ppm = 10.81 (s, 1H), 9.52 (s, 1H), 8.43 (s, 1H), 7.52 (m, 4H); 13C NMR (75 MHz, DMSO) δ/ppm = 164.9, 152.3, 143.5, 136.2, 131.3, 129.7, 127.2, 125.8.
References
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 5, p. 1672 - 1681
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 20, p. 4434 - 4436
[3] Patent: CN106986825, 2017, A
[4] Journal of Agricultural and Food Chemistry, 2018, vol. 66, # 34, p. 8957 - 8965
Isoquinoline-3-carboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30228 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from Isoquinoline-3-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-18 | Isoquinoline-3-carboxylic acid
6624-49-3
|
US $1.10 / g | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-04-04 | Isoquinoline-3-carboxylic acid
6624-49-3
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
|
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2019-12-26 | Isoquinoline-3-carboxylic acid
6624-49-3
|
US $6.60 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- Isoquinoline-3-carboxylic acid
6624-49-3
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- Isoquinoline-3-carboxylic acid
6624-49-3
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Isoquinoline-3-carboxylic acid
6624-49-3
- US $6.60 / KG
- 97%-99%
- Career Henan Chemical Co
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