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METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE structure

CAS No.: 80657-57-4

Chemical Name:: METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE

Synonyms: Methyl (S)-3-hydroxy-2-methylpropanoate;3-hydroxy-(2S)-methylpropionate;(S)-Roche ester;methyl beta-hydroxyisobutyrate;Methyl (S)-3-hydroxyisobutanoate;(+)-methyl l-β-hydroxyisobutyrate;METHYL L-(S)-3-HYDROXYISOBUTYRATE;METHYL (S)-(+)-3-HYDROXYISOBUTYRATE;(S)-(+)-METHYL B-HYDROXYISOBUTYRATE;Methyl-L-(S)-beta-hydroxyisobutyrate

CBNumber:: CB6777045

Molecular Formula:: C5H10O3

Molecular Weight:: 118.13

MDL Number:: MFCD00064520

MOL File:: 80657-57-4.mol

MSDS File:: SDS

Last updated:2026-01-13 11:23:32

Product description	Number	Pack Size	Price
Methyl (S)-(+)-3-hydroxy-2-methylpropionate 98%	270121	5g	$179.4
Methyl (S)-(+)-3-hydroxy-2-methylpropionate 98%	270121	25g	$782.85
Methyl (S)-(+)-3-hydroxy-2-methylpropionate 98%	270121	100g	$2450
Methyl (S)-(+)-3-hydroxy-2-methylpropionate	M312775	1g	$110
(S)-methyl3-hydroxy-2-methylpropanoate ≥97.0%	CS-W023098	5g	$110
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METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE Properties

Boiling point	74 °C/10 mmHg (lit.)
Density	1.071 g/mL at 25 °C (lit.)
refractive index	n20/D 1.425
Flash point	178 °F
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Liquid
pka	14.40±0.10(Predicted)
Specific Gravity	1.07
color	Colorless
optical activity	[α]19/D +26°, c = 4 in methanol
Water Solubility	Insoluble in water. Soluble in methanol.
BRN	1720830
InChI	InChI=1S/C5H10O3/c1-4(3-6)5(7)8-2/h4,6H,3H2,1-2H3/t4-/m0/s1
InChIKey	ATCCIZURPPEVIZ-BYPYZUCNSA-N
SMILES	C(OC)(=O)[C@@H](C)CO
CAS DataBase Reference	80657-57-4(CAS DataBase Reference)
UNSPSC Code	12352108
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H227-H315-H319-H335

Precautionary statements

P210e-P261-P280a-P305+P351+P338-P405-P501a

PPE

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Hazard Codes

Risk Statements

36/37/38-20/21/22

Safety Statements

26-36/37/39-36-24/25

RIDADR

1993

WGK Germany

HazardClass

3.2

PackingGroup

III

HS Code

29181990

Storage Class

10 - Combustible liquids

NFPA 704

	2
2		0

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	270121	Methyl (S)-(+)-3-hydroxy-2-methylpropionate 98%	80657-57-4	5g	$179.4	2025-07-31	Buy
Sigma-Aldrich	270121	Methyl (S)-(+)-3-hydroxy-2-methylpropionate 98%	80657-57-4	25g	$782.85	2025-07-31	Buy
Sigma-Aldrich	270121	Methyl (S)-(+)-3-hydroxy-2-methylpropionate 98%	80657-57-4	100g	$2450	2025-07-31	Buy
TRC	M312775	Methyl (S)-(+)-3-hydroxy-2-methylpropionate	80657-57-4	1g	$110	2021-12-16	Buy
ChemScene	CS-W023098	(S)-methyl3-hydroxy-2-methylpropanoate ≥97.0%	80657-57-4	5g	$110	2021-12-16	Buy

Product number	Packaging	Price	Buy
270121	5g	$179.4	Buy
270121	25g	$782.85	Buy
270121	100g	$2450	Buy
M312775	1g	$110	Buy
CS-W023098	5g	$110	Buy

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE Chemical Properties,Uses,Production

Chemical Properties

Clear colorless liquid

Uses

Methyl (S)-(+)-3-hydroxy-2-methylpropionate is used as a starting material for the synthesis of dictyostatin, discodermolide and spongidepsin.

Synthesis

15484-46-5

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE

80657-57-4

(R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER

72657-23-9

General procedure for the synthesis of methyl (S)-(+)-3-hydroxy-2-methylpropanoate and (-)-methyl-D-BATA-hydroxyisobutyrate from methyl 2-(hydroxymethyl)acrylate: K.3. Typical method for asymmetric catalytic hydrogenation is as follows: [Rh(COD)L*]BF4 (0.005 mmol, 1 mol%) and substrate (0.5 mmol) were were dissolved in a dry solvent (7.5 mL) and the solution was transferred to a stainless steel autoclave. After sealing the autoclave, it was purged with hydrogen and then pressurized with hydrogen. After stirring the reaction mixture for 16 h at room temperature, the hydrogen was slowly released to atmospheric pressure and the reaction solution was transferred to a round bottom flask. The solvent was removed using a rotary evaporator to obtain the crude product. The crude product was purified by silica gel column chromatography to give the hydrogenated product. The enantiomeric excess value of the product was determined by chiral column HPLC. The results of asymmetric catalytic hydrogenation using rhodium complexes of ligands (1-48) or (1-49) are presented in Tables 9 and 10, respectively. Table 9 demonstrates the results of asymmetric catalytic hydrogenation of rhodium complexes of ligand (1-48) under different conditions including substrate, solvent, pressure, conversion and enantiomeric excess values. Table 10, on the other hand, shows the results of asymmetric catalytic hydrogenation of rhodium complexes of ligand (I'-49c) under the same conditions.

References

[1] Advanced Synthesis and Catalysis, 2003, vol. 345, # 1-2, p. 185 - 189
[2] Advanced Synthesis and Catalysis, 2007, vol. 349, # 10, p. 1592 - 1596
[3] Tetrahedron Asymmetry, 2009, vol. 20, # 2, p. 210 - 213
[4] Advanced Synthesis and Catalysis, 2008, vol. 350, # 10, p. 1610 - 1614

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE synthesis

Synthesis of METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE from Methyl 2-(hydroxymethyl)acrylate

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE Preparation Products And Raw materials

Raw materials

Methyl 2-(hydroxymethyl)acrylate Dichloromethane 1,5-Cyclooctadiene Hydrogen

Preparation Products

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE Suppliers

Global( 185)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
TianYuan Pharmaceutical CO.,LTD	+86-755-23284190 13684996853	sales@tianpharm.com	CHINA	304	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14343	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Chemsigma International Co., Ltd.	+86-2558742998 +86-19951791336	info@chemsigma.com	China	1801	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15081	58

Supplier	Advantage
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
TianYuan Pharmaceutical CO.,LTD	58
Changzhou Ansciep Chemical Co., Ltd.	58
Accela ChemBio Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Win-Win chemical CO., Limited	58
ANHUI WITOP BIOTECH CO., LTD	58
Chemsigma International Co., Ltd.	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-04	METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE 80657-57-4	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2019-07-06	METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE 80657-57-4	US $1.00 / KG	1KG	98%	100kg	Career Henan Chemical Co

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE
80657-57-4
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE
80657-57-4
US $1.00 / KG
98%
Career Henan Chemical Co

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE Spectrum

METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE(80657-57-4)MS METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE(80657-57-4)¹HNMR METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE(80657-57-4)IR1 METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE(80657-57-4)Raman

80657-57-4(METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE)Related Search:

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2,2-DIMETHYL-5-PHENYL-1,3-DIOXANE-4,6-DIONE (R)-(-)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER Methyl 2-hydroxyisobutyrate

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(S)-(+)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER (S)-3-HYDROXY-2-METHYLPROPIONIC ACID METHYL ESTER (S)-(+)-3-HYDROXYISOBUTYRIC ACID METHYL ESTER methyl (S)-(+)-3-hydroxy-2-methyl-*propionate 99% methyl beta-hydroxyisobutyrate (+)-Methyl (S)-3-hydroxy-2-methylpropionate, S-(+)-3-Hydroxy-2-methylpropionic acid methyl ester (+)-Methyl L-β-hydroxyisobutyrate, S-(+)-3-Hydroxy-2-methylpropionic acid methyl ester Methyl-L-(S)-beta-hydroxyisobutyrate METHYL (S)-(+)-3-HYDROXY-2-METHYL-PROPIO NATE, 99% (99% EE/GLC) Propanoic acid, 3-hydroxy-2-methyl-, methyl ester, (2S)- (+)-methyl l-β-hydroxyisobutyrate 3-hydroxyisobutyric acid methyl ester (2S)-3-Hydroxy-2-methylpropanoic acid methyl ester (S)-2-Methyl-3-hydroxypropionic acid methyl ester Methyl (S)-3-hydroxyisobutanoate Methyl 3-hydroxy-(2S)-methylpropanoate (S)-Methyl 3-hydroxy-2-Methylpropanoate (S)-(+)-3-Hydroxyisobutyric Acid Methyl Ester (S)-(+)-3-Hydroxy-2-methylpropionic Acid Methyl Ester Methyl (S)-(+)-3-Hydroxy-2-methylpropionate (S)-(+)-METHYL 3-HYDROXY-2-METHYLPROPION (2S)-3-Hydroxy-2-methylpropionic acid methyl ester (S)-3-Hydroxy-2-methylpropanoic acid methyl ester 3-hydroxy-(2S)-methylpropionate Methyl (S)-(+)-3-hydroxy-2-Methylpropionate, ee: 98% L-(S)-(+)-3-HYDROXYISOBUTYRIC ACID METHYL ESTER L(+)-BETA-HYDROXYISOBUTYRIC ACID METHYL ESTER METHYL (S)-(+)-3-HYDROXY-2-METHYLPROPIONATE METHYL (S)-3-HYDROXY-2-METHYLPROPIONATE METHYL (S)-(+)-3-HYDROXYISOBUTYRATE (+)-METHYL L-BETA-HYDROXYISOBUTYRATE METHYL L-(S)-3-HYDROXYISOBUTYRATE (S)-(+)-Methyl 3-hydroxy-2-methylpropionate for synthesis 3-Hydroxy-2-methyl-propionic acid methyl ester ( Methyl (S)-(+)-3-hydroxy-2-methyl- propionate ) methyl (2S)-3-hydroxy-2-methylpropanoate Propanoicacid,3-hydroxy-2-methyl-methylester (S)-(+)-METHYL 3-HYDROXY-2-METHYLPROPIONATE (S)-(+)-METHYL B-HYDROXYISOBUTYRATE Methyl (S)-(+)-3-hydroxy-2-methylpropionate, 99%, ee: 98% Methyl(S)-(+)-3-Hydroxyisobutyrate> Methyl (S)-3-hydroxy-2-methylpropanoate methyI (S)-3-yrxy-2-methylpropanoate (S)-Roche ester Methyl (S)-(+)-3-hydroxy-2-methylpropionate 80657-57-4 HOCH2CHCH3CO2CH3 Building Blocks for Liquid Crystals Esters (Chiral) Chiral Compounds (Building Blocks for Liquid Crystals) Chiral Building Blocks Asymmetric Synthesis Organic Building Blocks Esters Building Blocks for Liquid Crystals Chiral Building Blocks Chiral Compounds (Building Blocks for Liquid Crystals) Esters (Chiral) Functional Materials Synthetic Organic Chemistry