6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt
![6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt Structure](CAS2/GIF/479347-86-9.gif)
- CAS No.
- 479347-86-9
- Chemical Name:
- 6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt
- Synonyms
- NSC7169;NSC 7169;NSC-7169;NBQX sodium;3-dione . 2Na;NBQX (sodium salt);FG 9202 disodium salt;NBQX disodium salt - Bio-X ?;6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2;NBQX disodium salt, AMPA / kainate antagonist
- CBNumber:
- CB72511387
- Molecular Formula:
- C24H14N8Na2O12S2
- Molecular Weight:
- 716.5239
- MDL Number:
- MFCD12910445
- MOL File:
- 479347-86-9.mol
| Product description | Number | Pack Size | Price |
| NBQX (sodium salt) ≥98% | 14914 | 10mg | $111 |
| NBQX(sodiumsalt) ≥98% | 14914 | 100mg | $874 |
| NBQX (sodium salt) ≥98% | 14914 | 5mg | $65 |
| NBQX (sodium salt) ≥98% | 14914 | 25mg | $262 |
| NBQX (sodium salt) ≥98% | 14914 | 50mg | $493 |
| storage temp. | -20°C Freezer |
|---|---|
| solubility | Soluble in H2O |
| form | crystalline solid |
| color | Orange |
| Water Solubility | Soluble to 100 mM in water |
| Stability | Store in Freezer at -20°C |
| FDA UNII | FSU8N86V27 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14914 | NBQX (sodium salt) ≥98% | 479347-86-9 | 10mg | $111 | 2024-03-01 | Buy |
| Cayman Chemical | 14914 | NBQX(sodiumsalt) ≥98% | 479347-86-9 | 100mg | $874 | 2024-03-01 | Buy |
| Cayman Chemical | 14914 | NBQX (sodium salt) ≥98% | 479347-86-9 | 5mg | $65 | 2021-12-16 | Buy |
| Cayman Chemical | 14914 | NBQX (sodium salt) ≥98% | 479347-86-9 | 25mg | $262 | 2024-03-01 | Buy |
| Cayman Chemical | 14914 | NBQX (sodium salt) ≥98% | 479347-86-9 | 50mg | $493 | 2024-03-01 | Buy |
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt Chemical Properties,Uses,Production
Chemical Properties
Deep Red-Brown Solid
Uses
A potent and discriminating antagonist for AMPA binding sites.
Biological Activity
nbqx disodium salt is a potent, highly selective and competitive antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (ampa) receptors (ampars). the ampar is one type of ionotropic glutamate receptors, well known to be involved in various neurological disorders such as alzheimer disease, schizophrenia, and epilepsy, by mediating long-term potentiation, excitotoxicity, or both. inhibition of ampars with nbqx shows neuroprotective and anticonvulsant activity.1. fukushima k, tabata y, imaizumi y, et al. characterization of human hippocampal neural stem/progenitor cells and their application to physiologically relevant assays for multiple ionotropic glutamate receptors. journal of biomolecular screening, 2014, 19(8): 1174-1184.2. chen w, li ys, gao j, et al. ampa receptor antagonist nbqx decreased seizures by normalization of perineuronal nets. plos one, 2016, 11(11): e0166672.
in vivo
NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ[2].
NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1].
| Animal Model: | Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)[2] |
| Dosage: | 20 mg/kg |
| Administration: | IP; for 3 days |
| Result: | Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats. |
storage
-20°C
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt Preparation Products And Raw materials
Raw materials
Preparation Products
6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2028 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
View Lastest Price from 6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione, Disodium Salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-21 | NBQX disodium
479347-86-9
|
US $35.00-123.00 / mg | 97.60% | 10g | TargetMol Chemicals Inc. |
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- NBQX disodium
479347-86-9
- US $35.00-123.00 / mg
- 97.60%
- TargetMol Chemicals Inc.
