Pixantrone (hydrochloride)
- CAS No.
- 175989-38-5
- Chemical Name:
- Pixantrone (hydrochloride)
- Synonyms
- Pixantrone (hydrochloride);6,9-bis(2-aminoethylamino)benzo[g]isoquinoline-5,10-dione:hydrochloride
- CBNumber:
- CB72668562
- Molecular Formula:
- C17H20ClN5O2
- Molecular Weight:
- 361.83
- MDL Number:
- MOL File:
- 175989-38-5.mol
| Melting point | 209-212° |
|---|---|
| FDA UNII | FC6HVZ9K78 |
Pixantrone (hydrochloride) Chemical Properties,Uses,Production
Uses
Pixantrone (BBR 2778 (free base)) hydrochloride, a mitoxantrone analog, is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity[1][2].
in vivo
Pixantrone (i.v., 27 mg/kg, every 7 days, three times) hydrochloride does not worsen pre-existing moderate degenerative cardiomyopathy, causes minimal cardiotoxic in mice following repeated treatment cycles and results in less mortality than mitoxantrone in doxorubicin-pretreated mice[3].
Pixantrone (i.v., 16.25 mg/kg, every week, three times) hydrochloride modulates Lymph node cells (LNC) responses, affacts T cell subpopulations in TAChR-immunized Lewis rats and also shows preventive and therapeutic effect in experimental autoimmune myasthenia gravis (EAMG) rats[4].
IC 50
Topoisomerase II
References
[1] Neil Beeharry, et al. Pixantrone induces cell death through mitotic perturbations and subsequent aberrant cell divisions. Cancer Biol Ther. 2015;16(9):1397-406. DOI:10.1080/15384047.2015.1070979
[2] Brian B Hasinoff, et al. Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform. J Pharmacol Exp Ther. 2016 Feb;356(2):397-409. DOI:10.1124/jpet.115.228650
[3] Ennio Cavalletti, et al. Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone. Invest New Drugs. 2007 Jun;25(3):187-95. DOI:10.1007/s10637-007-9037-8
[4] Federica Ubiali, et al. Pixantrone (BBR2778) reduces the severity of experimental autoimmune myasthenia gravis in Lewis rats. J Immunol. 2008 Feb 15;180(4):2696-703. DOI:10.4049/jimmunol.180.4.2696
Pixantrone (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Pixantrone (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
| ChemShuttle, Inc. | 0510-83588313-811 18800520310 | sales@chemshuttle.com | China | 2999 | 62 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59936 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29343 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| ChemShuttle, Inc. | 62 |
| Bide Pharmatech Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from Pixantrone (hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-27 | Pixantrone hydrochloride
175989-38-5
|
US $2140.00-3520.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Pixantrone hydrochloride
175989-38-5
- US $2140.00-3520.00 / mg
- TargetMol Chemicals Inc.
