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4-(4-Fluorobenzoyl)butyric acid

4-(4-Fluorobenzoyl)butyric acid structure

CAS No.: 149437-76-3

Chemical Name:: 4-(4-Fluorobenzoyl)butyric acid

Synonyms: 4-(4-FL;Ezetimibe-15;CAS:149437-76-3;CHEMBRDG-BB 4002813;TIMTEC-BB SBB000492;TIMTEC-BB SBB010216;4-(4-Fluorobenzoyl)b;Ezetimibe Impuriry P;4-(4-Fluorobenzoyl)butyric;4-FLUORO BENZOYL BUTYRIC ACID

CBNumber:: CB8168564

Molecular Formula:: C11H11FO3

Molecular Weight:: 210.2

MDL Number:: MFCD00667222

MOL File:: 149437-76-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:23:55

Product description	Number	Pack Size	Price
5-(4-FLUORO-PHENYL)-5-OXO-PENTANOIC ACID Aldrich^CPR	R169609	1 unit	$197
5-(4-FLUORO-PHENYL)-5-OXO-PENTANOIC ACID Aldrich	R169609	50mg	$179
4-(4-Fluorobenzoyl)butyric Acid >98.0%(GC)(T)	F0476	1g	$31
4-(4-Fluorobenzoyl)butyric Acid >98.0%(GC)(T)	F0476	5g	$40
4-Fluorophenyl-5’-oxobutyricAcid	F588495	5g	$140
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4-(4-Fluorobenzoyl)butyric acid Properties

Melting point	142-144°C
Boiling point	394.6±22.0 °C(Predicted)
Density	1.241±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO, Methanol
pka	4.59±0.10(Predicted)
form	Solid
color	Off-White
InChI	InChI=1S/C11H11FO3/c12-9-6-4-8(5-7-9)10(13)2-1-3-11(14)15/h4-7H,1-3H2,(H,14,15)
InChIKey	ZBQROUOOMAMCQW-UHFFFAOYSA-N
SMILES	C(C1C=CC(F)=CC=1)(=O)CCCC(=O)O
CAS DataBase Reference	149437-76-3(CAS DataBase Reference)
FDA UNII	Q9WD9HE8J3

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37

Hazard Note

Irritant

HS Code

29183000

NFPA 704

	0
2		0

4-(4-Fluorobenzoyl)butyric acid price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	R169609	5-(4-FLUORO-PHENYL)-5-OXO-PENTANOIC ACID Aldrich^CPR	149437-76-3	1 unit	$197	2026-03-19	Buy
Sigma-Aldrich	R169609	5-(4-FLUORO-PHENYL)-5-OXO-PENTANOIC ACID Aldrich	149437-76-3	50mg	$179	2024-03-01	Buy
TCI Chemical	F0476	4-(4-Fluorobenzoyl)butyric Acid >98.0%(GC)(T)	149437-76-3	1g	$31	2026-03-19	Buy
TCI Chemical	F0476	4-(4-Fluorobenzoyl)butyric Acid >98.0%(GC)(T)	149437-76-3	5g	$40	2026-03-19	Buy
TRC	F588495	4-Fluorophenyl-5’-oxobutyricAcid	149437-76-3	5g	$140	2021-12-16	Buy

Product number	Packaging	Price	Buy
R169609	1 unit	$197	Buy
R169609	50mg	$179	Buy
F0476	1g	$31	Buy
F0476	5g	$40	Buy
F588495	5g	$140	Buy

4-(4-Fluorobenzoyl)butyric acid Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

4-Fluorophenyl-5’-oxobutyric Acid (cas# 149437-76-3) is a compound useful in organic synthesis.

Synthesis

108-55-4

462-06-6

149437-76-3

4-(4-Fluorobenzoyl)butyric acid was synthesized as follows: 250 g of anhydrous AlCl3 (1.87 mol) and 300 mL of fluorobenzene (307.5 g; 3.2 mol) were added to a 2 L three-necked round-bottomed flask, and the mixture was cooled to 5 °C in an ice bath. A turbid suspension of 100 g of glutaric anhydride (0.86 mol) dissolved in 400 mL of fluorobenzene (4.3 mol) was slowly added through the addition funnel over 45 min, keeping the reaction temperature below 12 °C. The reaction mixture was gradually warmed to room temperature and stirred for 90 min and the completion of the reaction was monitored by NMR. The reaction mixture was cooled to 0 to 5 °C and 700 mL of a cold aqueous solution of 1N HCl was carefully added to quench unreacted AlCl3, keeping the temperature below 20 °C initially and not exceeding 40 °C later. The mixture was poured into 2 L of a 1:1 mixture of water and ice (v/w) to precipitate the crude product, and the white suspension was filtered and washed well with water. The white solid was dissolved in 3 L of 5% NaHCO3 saturated aqueous solution, heated in a steam bath for 1 h and then filtered through a diatomaceous earth pad while hot. The filtrate was cooled to room temperature, adjusted to pH 1 by adding about 320 mL of concentrated HCl drop by drop, the product crystallized and stirred in an ice bath for 30 minutes. Filtered, the wet filter cake was washed with ice-cold water and dried under vacuum at 50 °C for 16 h. 143.2 g of 4-(4-fluorobenzoyl)butyric acid was obtained with a melting point of 141 to 142 °C and a yield of 79.3%.

References

[1] Patent: WO2004/99132, 2004, A2. Location in patent: Page 7-8
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 15, p. 4424 - 4426
[3] Patent: CN106397292, 2017, A. Location in patent: Paragraph 0053; 0083; 0084
[4] Patent: US2006/135755, 2006, A1. Location in patent: Page/Page column 15
[5] Patent: EP1137634, 2005, B1. Location in patent: Page/Page column 9

4-(4-Fluorobenzoyl)butyric acid synthesis

Synthesis of 4-(4-Fluorobenzoyl)butyric acid from Glutaric anhydride and Fluorobenzene

4-(4-Fluorobenzoyl)butyric acid Preparation Products And Raw materials

Raw materials

Glutaric anhydride Pentanedioic acid, anhydride with pentanedioic acid Fluorobenzene

Preparation Products

(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone

4-(4-Fluorobenzoyl)butyric acid Suppliers

Global( 424)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
PRISUN PHARMATECH CO.,LTD	+86-021-54326183-8001 +8618917565227	prisun@prisunpharma.com	China	215	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8742	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Nanjing Gold Pharmaceutical Technology Co. Ltd.	025-84209270 15906146951		CHINA	115	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21594	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	info@tnjchem.com	China	2988	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29827	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58

Supplier	Advantage
PRISUN PHARMATECH CO.,LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Nanjing Gold Pharmaceutical Technology Co. Ltd.	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Shanghai Arbor Chemical Co., Ltd.	58

View Lastest Price from 4-(4-Fluorobenzoyl)butyric acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-30	4-(4-Fluorobenzoyl)butyric acid 149437-76-3	US $5.00 / kg	1kg	≥99%	100mt/year	Jinan Finer Chemical Co., Ltd
2026-03-20	4-(4-Fluorobenzoyl)butyric acid 149437-76-3	US $0.00-0.00 / kg	1kg	99%	100 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-08-26	4-(4-Fluorobenzoyl) butyric acid 149437-76-3	US $0.00-0.00 / kg	1kg	99%	1	Jinan Ruitong Biotech Co., Ltd.

4-(4-Fluorobenzoyl)butyric acid
149437-76-3
US $5.00 / kg
≥99%
Jinan Finer Chemical Co., Ltd

4-(4-Fluorobenzoyl)butyric acid
149437-76-3
US $0.00-0.00 / kg
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-(4-Fluorobenzoyl) butyric acid
149437-76-3
US $0.00-0.00 / kg
99%
Jinan Ruitong Biotech Co., Ltd.

4-(4-Fluorobenzoyl)butyric acid Spectrum

4-(4-Fluorobenzoyl)butyric acid(149437-76-3)¹HNMR

149437-76-3(4-(4-Fluorobenzoyl)butyric acid )Related Search:

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Butyric Acid 4-Fluorobenzamide Ezetimibe 5-(4-FLUOROPHENYL)VALERIC ACID ent-EzetiMibe

EzetiMibe (3R,4R,3'S)-IsoMer (R)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one (3R,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one (4S)-3-(2,2-dimethylpropanoyl)-4-phenyl-1,3-oxazolidin-2-one 4-BENZOYLBUTYRIC ACID

5-(2-FLUOROPHENYL)-5-OXOVALERIC ACID Ezetimibe Impurity 72 N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline

1of4

CHEMBRDG-BB 4002813 4-(4-FLUOROPHENYL)BUTYRIC ACID 4-(4-FLUOROBENZOYL)BUTYRIC ACID 4-(4-FLUOROBENZOYL)-1-BUTANOIC ACID 4-FLUORO-GAMMA-OXO-BENZENEPENTANOIC ACID 4-FLUOROPHENYL-5-OXOPENTANOIC ACID 4-FLUORO BENZOYL BUTYRIC ACID 5-(4'-FLUOROPHENYL)-5-OXOPENTANOIC ACID 5-(4-FLUOROPHENYL)-5-OXO-PENTANOIC ACID 5-(4-FLUOROPHENYL)-5-OXOVALERIC ACID 5-(P-FLUOROPHENYL)-5-OXO-PENTANOIC ACID 4-(4-Flurobenzoyl-)butyric Acid (FBBA) 4-(p-Fluorobenzoyl)-butyric acid TIMTEC-BB SBB000492 TIMTEC-BB SBB010216 4-(4-FL Ezetimibe-15 5-(4-FLUOROPHENYL)-5-OXOPENTANOIC ACID 4-(4-FLUOROPHENYL) BUTYRIC ACID 4-(Fluorobenzoyl)ButyricAcid,IntermediateOfEzetimibe 4-(Fluorobenzoyl) Butyric Acid Intermediate Of Ezetimibe (Apis) 4-Fluorophenyl-5oxobutyric Acid 4-(4-Fluorobenzoyl)butyric p-Fluorophenyl-5-oxo-pentansure 4-(4-Fluorophenyl)butanoic acid 98% 4-(4-Fluorobenzoyl)butanoic acid 4-FLUORO--OXO-BENZENEPENTANOIC ACID 4-fluorophenyl-5-ketopentanoic acid 5-(4-fluorophenyl)-5-ketopentanoic acid 4-fluoro-delta-oxo-benzenepentanoic acid 5-(4'-Fluorophenyl)-5-oxopenta 4-(4-Fluorobenzoyl)b 4-(4-Fluorobenzoyl)butanoic acid, 5-(4-Fluorophenyl)-5-oxovaleric acid Benzenepentanoic acid,4-fluoro-d-oxo- 5-(4-FLOUROPHENYL)-5-OXOPENTANOIC ACID 4-(4-Fluorobenzoyl)butyricAcid> Benzenepentanoic acid, 4-fluoro-δ-oxo- 4-(4-Fluorobenzoyl)ButyricAci Ezetimibe Impuriry P 4-(4'-Fluorophenyl)butyric acid (Ezetimibe Impurity) 4-(4-FLUOROBENZYL)BUTYRIC ACID 5-(4-Fluorophenyl)-5-Ketopentanoic acid(Keto acid) 4-Fluoro-δ-oxobenzenepentanoic acid 5-(4'-Fluorophenyl)-5-oxopentanoicacid 4-Fluorophenyl-5’-oxobutyric Acid 4-(4'-Fluorophenyl)butyric acid CAS:149437-76-3 Baclofen Impurity: 5-(4-Fluorophenyl)-5-oxopentanoic acid 149437-76-3 49437-76-3 C11H1FO3 Aromatics Intermediate of ezetimibe Acids & Esters Fluorine Compounds 149437-76-3