(1E,3E)-1-(4-フルオロフェニル)-2-メチル-1-ペンテン-3-オンオキシム
|
|
|
- CAS番号.
- 1170613-55-4
- 化学名:
- (1E,3E)-1-(4-フルオロフェニル)-2-メチル-1-ペンテン-3-オンオキシム
- 别名:
- (1E,3E)-1-(4-フルオロフェニル)-2-メチル-1-ペンテン-3-オンオキシム;(E)-N-[(1E)-1-(4-フルオロフェニル)-2-メチルペンタ-1-エン-3-イリデン]ヒドロキシルアミン
- 英語名:
- A 967079
- 英語别名:
- A 967079;A-967079, 10 mM in DMSO;A-967079, TRPA1 receptor antagonist;(1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe;(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime;1-Penten-3-one, 1-(4-fluorophenyl)-2-methyl-, oxime, (1E,3E)-;TRP Channel,inhibit,Transient receptor potential channels,A 967079,Inhibitor,A-967079,A967079
- CBNumber:
- CB22650391
- 化学式:
- C12H14FNO
- 分子量:
- 207.24
- MOL File:
- 1170613-55-4.mol
- MSDS File:
- SDS
|
(1E,3E)-1-(4-フルオロフェニル)-2-メチル-1-ペンテン-3-オンオキシム 物理性質
- 沸点 :
- 324.4±34.0 °C(Predicted)
- 比重(密度) :
- 1.03±0.1 g/cm3 (20 ºC 760 Torr)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：12mg/mL以上
- 外見 :
- 粉
- 酸解離定数(Pka):
- 12.23±0.40(Predicted)
- 色:
- 白から黄褐色
- 安定性：:
- 購入日から2年間安定です。この DMSO 溶液は、-20°C で 2 か月間保存できます。
- InChI:
- InChI=1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+
- InChIKey:
- HKROEBDHHKMNBZ-CHBKHGQFSA-N
- SMILES:
- C(/C1=CC=C(F)C=C1)=C(/C)\C(=N\O)\CC
(1E,3E)-1-(4-フルオロフェニル)-2-メチル-1-ペンテン-3-オンオキシム 価格
もっと(9)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC4716 |
A 967079 |
1170613-55-4 |
10mg |
￥57000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQK-7565 |
(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one oxime |
1170613-55-4 |
100mg |
￥475000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0085 |
≥98% (HPLC)
A-967079 ≥98% (HPLC) |
1170613-55-4 |
5mg |
￥19700 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
SML0085 |
≥98% (HPLC)
A-967079 ≥98% (HPLC) |
1170613-55-4 |
25mg |
￥125000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01W0101-2698 |
A-967079 |
1170613-55-4 |
10mg |
￥18000 |
2024-03-01 |
購入 |
(1E,3E)-1-(4-フルオロフェニル)-2-メチル-1-ペンテン-3-オンオキシム 化学特性,用途語,生産方法
外観
白色～褐色、結晶～粉末
溶解性
ジメチルスルホキシド溶状：試験適合ジメチルスルホキシドに溶ける。
使用
(1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain.
一般的な説明
A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.
Biochem/physiol Actions
A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC50′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.
Advantages
(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime (A-967079) has shown impressive efficacy as an antagonist to TRPA1 and has multiple advantages over other compounds, including high selectivity, potency, and oral bioavailability. A-967079 has IC50 values of 67 and 289 nM for human and rat TRPA1 receptors, respectively. It displays 1000-fold selectivity for TRPA1 over other TRP channels, and >150-fold selectivity for over 75 other ion channels, enzymes and G-protein-coupled receptors. Oral administration of A-967079 in rats produced robust bioavailability and analgesic efficacy for TIH-induced pain response (i.e., sneezing, tearing, coughing, etc.) and osteoarthritic pain. Intravenous injection of A-967079 has shown to decrease the reactive gas response of wide dynamic range neurons (i.e., a second-order neuron that responds to more than one type of stimulus) and pain specific-neurons. Aditionally, A-967079 produces no known locomotor or cardiovascular effects, a common side effect of other TRP antagonists[2].
(1E,3E)-1-(4-フルオロフェニル)-2-メチル-1-ペンテン-3-オンオキシム 上流と下流の製品情報
原材料
準備製品
(1E,3E)-1-(4-フルオロフェニル)-2-メチル-1-ペンテン-3-オンオキシム 生産企業
Global( 96)Suppliers
(1E,3E)-1-(4-フルオロフェニル)-2-メチル-1-ペンテン-3-オンオキシム スペクトルデータ(1HNMR)
1170613-55-4((1E,3E)-1-(4-フルオロフェニル)-2-メチル-1-ペンテン-3-オンオキシム)キーワード:
- 1170613-55-4
- A 967079
- (1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe
- (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-pentene-3-one oxime
- 1-Penten-3-one, 1-(4-fluorophenyl)-2-methyl-, oxime, (1E,3E)-
- TRP Channel,inhibit,Transient receptor potential channels,A 967079,Inhibitor,A-967079,A967079
- A-967079, TRPA1 receptor antagonist
- A-967079, 10 mM in DMSO
- (1E,3E)-1-(4-フルオロフェニル)-2-メチル-1-ペンテン-3-オンオキシム
- (E)-N-[(1E)-1-(4-フルオロフェニル)-2-メチルペンタ-1-エン-3-イリデン]ヒドロキシルアミン