Carmustine manufacturers and suppliers

Carmustine suppliers

Properties

Melting point:: 30 °C (lit.)

Density: 1.6948 (rough estimate)

refractive index: 1.6100 (estimate)

storage temp.: -20°C

solubility: insoluble in H2O; ≥21.51 mg/mL in DMSO; ≥27.15 mg/mL in EtOH

form: (Oily liquid to amorphous solid)

pka: 10.19±0.46(Predicted)

color: Light-yellow powder

Water Solubility: <0.1 g/100 mL at 18 ºC

Merck: 14,1845

Stability:: Temperature Sensitive

InChI: 1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)

InChIKey: DLGOEMSEDOSKAD-UHFFFAOYSA-N

SMILES: ClCCNC(=O)N(CCCl)N=O

CAS DataBase Reference: 154-93-8(CAS DataBase Reference)

IARC: 2A (Vol. 26, Sup 7) 1987

EPA Substance Registry System: 1,3-Bis(2-chloroethyl)-1-nitrosourea (154-93-8)

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H300-H350-H360

Precautionary statements: P201-P280-P301+P330+P331+P310-P308+P313

PPE: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes: T+

Risk Statements: 45-46-60-61-28

Safety Statements: 53-22-36/37/39-45

RIDADR: 3249

WGK Germany: 3

RTECS: YS2625000

HazardClass: 6.1(a)

PackingGroup: II

HS Code: 29241990

Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications: Acute Tox. 2 Oral
Carc. 1B
Repr. 1B

Hazardous Substances Data: 154-93-8(Hazardous Substances Data)

Toxicity: LD50 in mice (mg/kg): 19-25 orally, 26 i.p., 24 s.c.; in rats (mg/kg): 30-34 orally (Thompson, Larson)

Use

Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent. It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis. Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase. Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.

You can find Carmustine suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.