Pravastatin manufacturers and suppliers

Pravastatin suppliers

Properties

Melting point:: 171.2-173 °C

Boiling point:: 634.5±55.0 °C(Predicted)

Density: 1.21±0.1 g/cm3(Predicted)

storage temp.: Sealed in dry,Room Temperature

solubility: H₂O: 19 mg/mL

pka: 4.31±0.10(Predicted)

form: powder

color: white

InChIKey: VWBQYTRBTXKKOG-SYYCFNTLNA-M

SMILES: C12=C[C@@H](O)C[C@H](OC([C@@H](C)CC)=O)[C@]1([H])[C@H]([C@@H](C)C=C2)CC[C@@H](O)C[C@@H](O)CC(=O)[O-].[Na+] |&1:2,5,8,13,15,16,22,25,r|

CAS DataBase Reference: 81093-37-0(CAS DataBase Reference)

EPA Substance Registry System: 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-.beta.,.delta.,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-, (.beta.R,.delta,R,1S,2S,6S,8S,8aR)- (81093-37-0)

Safety Information

Symbol(GHS): GHS08,GHS09

Signal word: Danger

Hazard statements: H350-H360--H410

Precautionary statements: P273-P260-P314-P501

Hazard Codes: F,C

Risk Statements: 11-34

Safety Statements: 16-26-36/37/39-45

WGK Germany: 2

RTECS: QJ7185000

Hazardous Substances Data: 81093-37-0(Hazardous Substances Data)

Use

Pravastatin, sodium 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoate (Pravachol), is the most rapid actingof the three HMG-CoA reductase inhibitor drugs, reachinga peak concentration in about 1 hour. The sodium salt of theβ-hydroxy acid is more hydrophilic than the lactone forms ofthe other two agents, which may explain this property. In addition,the open form of the lactone ring contributes to a morehydrophilic agent, which, in turn, results in less CNS penetration.This explains, in part, why pravastatin has fewer CNSside effects than the more lipophilic lactone ester of this classof agents. Absorption of pravastatin following oral administrationcan be inhibited by resins such as cholestyramine becauseof the presence of the carboxylic acid function on thedrug. The lactone forms of lovastatin and simvastatin are lessaffected by cholestyramine.

You can find Pravastatin suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.