BIS(METHYLTHIO)GLIOTOXIN
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- $86 - $802
- Product name: BIS(METHYLTHIO)GLIOTOXIN
- CAS: 74149-38-5
- MF: C15H20N2O4S2
- MW: 356.46
- EINECS:
- MDL Number:MFCD00133146
- Synonyms:gliotoxin, bis-dethio-bis(methylthio)-;(3R)-2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3α,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;2,3,5aβ,6,10,10a-Hexahydro-6β-hydroxy-3β-(hydroxymethyl)-2-methyl-3,10aα-bis(methylthio)pyrazino[1,2-a]indole-1,4-dione;Bis(methylthio)gliotoxin (FR-49175);BIS(METHYLTHIO)GLIOTOXIN;FR-49175;bis-dethio-bis(methylthio)gliotoxin;Pyrazino[1,2-a]indole-1,4-dione, 2,3,5a,6,10,10a-hexahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-3,10a-bis(methylthio)-, (3R,5aS,6S,10aR)-
6 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Crysdot
- TRC
Package
- 500μg
- 1mg
- 2.5mg
- 5mg
- ManufacturerAK Scientific
- Product number2418CB
- Product descriptionBisdethiobis(methylthio)gliotoxin
- Packaging1mg
- Price$276
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number26271
- Product descriptionBis(methylthio)gliotoxin ≥95%
- Packaging500μg
- Price$86
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number26271
- Product descriptionBis(methylthio)gliotoxin ≥95%
- Packaging1mg
- Price$161
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD32000504
- Product descriptionBis(methylthio)gliotoxin 95+%
- Packaging5mg
- Price$802
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberB485948
- Product descriptionBis(methylthio)gliotoxin(FR-49175)
- Packaging1mg
- Price$215
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberB485948
- Product descriptionBis(methylthio)gliotoxin(FR-49175)
- Packaging2.5mg
- Price$525
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2418CB | Bisdethiobis(methylthio)gliotoxin | 1mg | $276 | 2021-12-16 | Buy |
| Cayman Chemical | 26271 | Bis(methylthio)gliotoxin ≥95% | 500μg | $86 | 2024-03-01 | Buy |
| Cayman Chemical | 26271 | Bis(methylthio)gliotoxin ≥95% | 1mg | $161 | 2024-03-01 | Buy |
| Crysdot | CD32000504 | Bis(methylthio)gliotoxin 95+% | 5mg | $802 | 2021-12-16 | Buy |
| TRC | B485948 | Bis(methylthio)gliotoxin(FR-49175) | 1mg | $215 | 2021-12-16 | Buy |
| TRC | B485948 | Bis(methylthio)gliotoxin(FR-49175) | 2.5mg | $525 | 2021-12-16 | Buy |
Properties
Boiling point :669.6±55.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
form :White solid.
pka :12.69±0.60(Predicted)
color :Off-White to Yellow
biological source :natural
Water Solubility :water: soluble
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :Chloroform (Slightly), Methanol (Slightly)
form :White solid.
pka :12.69±0.60(Predicted)
color :Off-White to Yellow
biological source :natural
Water Solubility :water: soluble
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||
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Description
Bis(methylthio)gliotoxin (FR-49175) is a toxic metabolite with anthiphagocytic and immunosuppressive properties synthesized by pathogenic fungi such as Aspergillus fumigatus. Bis(methylthio)gliotoxin (FR-49175) is an analog of gliotoxin known to inhibit PAF-induced platelet aggregation and collagen-aggregation, but has no activity with arachidonic or ADP induced aggregation. Shown to speed up PAF hydrolysis and inhibit PAF-mediated caspase 3 activation. From guinea-pig experiments, reported to Inhibit PAF-induced bronchoconstriction.Suppliers and manufacturers
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