| Company Name: |
Artis Biotech Co. Ltd.
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| Tel: |
19138486554; 18108108965 |
| Email: |
sales@artisbio.com |
| Products Intro: |
Product Name:Pimozide D4
Purity:98%HPLC Package:1mg 5mg 10mg 50mg
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| Company Name: |
Shenzhen SUNGENING Bio-Medical Co., Ltd.
|
| Tel: |
0755-0755-28967200-8062 13631290199 |
| Email: |
wxf@sungening.com |
| Products Intro: |
Product Name:Pimozide D4
Purity:99% HPLC or More Package:10MG;25MG;50MG;100MG
|
PiMozide-d4 manufacturers
- Pimozide-d4
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- $0.00 / 1mg
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2025-07-21
- CAS:1803193-57-8
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | PiMozide-d4 Basic information |
| Product Name: | PiMozide-d4 | | Synonyms: | PiMozide-d4;R6238 D4;1-[1-[4-(4-fluorophenyl)-4-(4-fluorophenyl-2,3,5,6-d4)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one;1-(1-{4-[4-fluoro(2,3,5,6-2H?)phenyl]-4-(4-fluorophenyl)butyl}piperidin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one;Pimozide-D4 solution | | CAS: | 1803193-57-8 | | MF: | C28H29F2N3O | | MW: | 461.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1803193-57-8.mol |  |
| | PiMozide-d4 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Acetonitrile:Methanol (1:1): soluble | | form | A solid | | color | White to off-white |
| | PiMozide-d4 Usage And Synthesis |
| Uses | Pimozide-d4 is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3]. | | IC 50 | Dopamine D2 receptor: 1.4 nM (Ki); opamine D3 receptor: 2.5 nM (Ki); opamine D1 receptor: 588 nM (Ki); α1-adrenoceptor: 39 nM (Ki); STAT3; STAT5 | | References | [1] Ybema CE, et al. Adrenoceptors and dopamine receptors are not involved in the discriminative stimulus effect of the 5-HT1A receptor agonist flesinoxan. Eur J Pharmacol. 1994 Apr 21;256(2):141-7. DOI:10.1016/0014-2999(94)90238-0
[2] Cai N, et al. The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression. Am J Transl Res. 2017 Aug 15;9(8):3853-3866. eCollection 2017. PMID:28861175
[3] Erik A. Nelson, et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011 Mar 24; 117(12): 3421-3429. DOI:10.1182/blood-2009-11-255232 |
| | PiMozide-d4 Preparation Products And Raw materials |
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