| Company Name: |
Cell Signaling Technology Inc
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| Tel: |
21-80243558 86218024 |
| Email: |
info@cellsignal.cn |
| Products Intro: |
Product Name:CENP-I (D4D5K) Rabbit mAb
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| | CENP-I (D4D5K) Rabbit mAb Chemical Properties |
| | CENP-I (D4D5K) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | Kinetochores are mitotic structures that form on centromeres and attach to mitotic spindle microtubules. Kinetochore attachment to microtubules regulates chromosome segregation and progression through mitosis. Unattached kinetochores signal to the spindle assembly checkpoint machinery, arresting cells in mitosis.CENP-I is a centromere protein associated with the inner kinetochore, and required for progression through mitosis and the appropriate localization of other kinetochore-associated and checkpoint proteins, including CENP-C, the RZZ complex, MAD1 and MAD2. | | References | [1] Foley, E.A. and Kapoor, T.M. (2013) Nat Rev Mol Cell Biol 14, 25-37.
[2] Nishihashi, A. et al. (2002) Dev Cell 2, 463-76.
[3] Matson, D.R. and Stukenberg, P.T. (2014) J Cell Biol 205, 541-54.
[4] Liu, S.T. et al. (2003) Nat Cell Biol 5, 341-5. |
| | CENP-I (D4D5K) Rabbit mAb Preparation Products And Raw materials |
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