TNFRSF11A抗体,Mouse Monoclonal TNFRSF11A Antibody
  • TNFRSF11A抗体,Mouse Monoclonal TNFRSF11A Antibody
  • TNFRSF11A抗体,Mouse Monoclonal TNFRSF11A Antibody
  • TNFRSF11A抗体,Mouse Monoclonal TNFRSF11A Antibody

TNFRSF11A抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-15
QQ交谈 微信洽谈

产品详情

中文名称:TNFRSF11A抗体英文名称:Mouse Monoclonal TNFRSF11A Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1091 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: TNFRSF11A
2025-05-15 TNFRSF11A抗体 Mouse Monoclonal TNFRSF11A Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1091 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesFEO; OFE; ODFR; OSTS; PDB2; RANK; CD265; OPTB7; TRANCER; LOH18CR1
Entrez GeneID8792
clone8H8B2
WB Predicted band size66kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TNFRSF11A (AA: extra 30-212) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

+ +

  •  

     

       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


  •  

     

       Flow cytometric analysis of Hela cells using TNFRSF11A mouse mAb (green) and negative control (red).    


  •  

     

       Flow cytometric analysis of HL-60 cells using TNFRSF11A mouse mAb (green) and negative control (red).    


           

参考文献

以下是关于TNFRSF11A(RANK)抗体的模拟参考文献示例,格式为文献名称、作者及摘要概括:

---

1. **"A neutralizing antibody targeting RANK treats osteoporosis by inhibiting osteoclastogenesis"**

*作者:Li J, et al. (2018)*

**摘要**:研究报道了一种中和性抗RANK抗体,通过阻断RANKL-RANK相互作用抑制破骨细胞分化,在骨质疏松小鼠模型中显著减少骨吸收并增加骨密度。

2. **"Structural basis of RANK recognition by a therapeutic antibody for bone metastasis"**

*作者:Yamaguchi K, et al. (2020)*

**摘要**:利用冷冻电镜解析了抗RANK抗体与TNFRSF11A的复合物结构,揭示了抗体结合表位,为设计靶向RANK的癌症骨转移治疗药物提供结构依据。

3. **"Agonistic anti-RANK antibody promotes bone regeneration in a murine model"**

*作者:Smith RP, et al. (2019)*

**摘要**:开发了一种激动型RANK抗体,通过激活RANK信号通路刺激成骨细胞活性,在小鼠骨缺损模型中加速骨再生,提示其潜在临床应用价值。

4. **"RANK-specific autoantibodies in autoimmune hypoparathyroidism"**

*作者:Garcia-Carrasco M, et al. (2015)*

**摘要**:在自身免疫性甲状旁腺功能减退症患者中发现抗RANK自身抗体,可能通过干扰RANK信号通路导致钙代谢异常,为疾病机制研究提供新方向。

---

**注意**:以上文献为示例,实际引用时请核实真实来源及内容。建议通过PubMed、Google Scholar等平台检索关键词(如“TNFRSF11A antibody”“RANK antibody therapeutic”)获取准确文献信息。

       

背景信息

TNFRSF11A (tumor necrosis factor receptor superfamily member 11A), also known as RANK (receptor activator of nuclear factor kappa-B), is a transmembrane receptor primarily involved in regulating osteoclast differentiation, bone remodeling, and immune cell activation. It binds to its ligand RANKL (RANK ligand), initiating signaling cascades that influence bone metabolism, lymph node development, and thermoregulation. Dysregulation of the RANKL/RANK/OPG (osteoprotegerin) axis is implicated in osteoporosis, rheumatoid arthritis, bone metastases, and rare genetic disorders like familial expansile osteolysis.

TNFRSF11A antibodies are essential tools for studying this receptor’s expression, signaling, and pathological roles. Polyclonal and monoclonal antibodies targeting specific extracellular or intracellular domains are used in techniques like Western blot, immunohistochemistry (IHC), and flow cytometry to detect RANK expression in tissues or cells. Researchers also employ blocking antibodies to inhibit RANKL-RANK interactions, elucidating their functional roles in bone resorption or cancer progression.

Clinically, anti-RANKL therapies (e.g., denosumab) mimic antibody mechanisms to treat bone loss, but direct TNFRSF11A antibodies remain investigational. Their development faces challenges, including balancing therapeutic efficacy with potential immune-related side effects. Ongoing research explores their utility in targeting RANK-expressing cancer cells or modulating immune responses in autoimmune diseases.

       
关键字: TNFRSF11A抗体;TNFRSF11A;TNFRSF11A Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

TNFRSF11A抗体—艾普蒂相关厂家报价

产品名称 价格   公司名称 报价日期
¥960.00
VIP10年
北京索莱宝科技有限公司
2026-03-04
¥1950
VIP4年
上海沪震实业有限公司
2026-03-05
询价
碧云天生物技术有限公司
2026-03-03
¥1280
湖北艾普蒂生物工程有限公司
2025-06-09
内容声明:
以上所展示的信息由商家自行提供,内容的真实性、准确性和合法性由发布商家负责。 商家发布价格指该商品的参考价格,并非原价,该价格可能随着市场变化,或是由于您购买数量不同或所选规格不同而发生变化。最终成交价格,请咨询商家,以实际成交价格为准。请意识到互联网交易中的风险是客观存在的
主页 | 企业会员服务 | 广告业务 | 联系我们 | 旧版入口 | 中文MSDS | CAS Index | 常用化学品CAS列表 | 化工产品目录 | 新产品列表 |投诉中心
Copyright © 2008 ChemicalBook 粤ICP备2021105330号-3  京公海网安备110108000080号  All rights reserved.