1-METHOXY-4-(METHYLTHIO)BENZENE synthesis
- Product Name:1-METHOXY-4-(METHYLTHIO)BENZENE
- CAS Number:1879-16-9
- Molecular formula:C8H10OS
- Molecular Weight:154.23
624-92-0
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$20.63/5 mL
696-62-8
357 suppliers
$5.00/1g
1879-16-9
123 suppliers
$10.00/1g
Yield:1879-16-9 78%
Reaction Conditions:
with tetrabutylammomium bromide;copper(II) acetate monohydrate;potassium hydroxide in water at 100; for 12 h;Catalytic behavior;Sealed tube;Reagent/catalyst;Temperature;
Steps:
(Het)aryl Methyl Sulfides; General Procedure
General procedure: A 25-mL sealable tube was charged with the appropriate aryliodide or bromide (1.0 mmol), dimethyl disulfide (1.2 mmol),Cu(OAc)2·H2O (0.1 mmol), KOH (2.0 mmol), TBAB (0.05 mmol),and H2O (2.0 mL). The mixture was stirred at 100 °C (130 °C forbromides) for 12 h under air then cooled to r.t. The mixture wasdiluted with H2O (5 mL) and extracted with EtOAc (4 × 10 mL).The extracts were combined, washed with brine (3 × 10 mL),dried (MgSO4), filtered, and concentrated. The residue was purifiedby chromatography [silica gel, EtOAc–hexane (1:30 to1:100)].
References:
Wang, Ying-Yu;Wu, Xiang-Mei;Yang, Ming-Hua [Synlett,2020] Location in patent:supporting information
624-92-0
353 suppliers
$20.63/5 mL
104-94-9
499 suppliers
$9.00/1g
1879-16-9
123 suppliers
$10.00/1g
3517-99-5
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1879-16-9
123 suppliers
$10.00/1g
696-62-8
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$5.00/1g
67-68-5
1333 suppliers
$15.00/100g
1879-16-9
123 suppliers
$10.00/1g
93-58-3
512 suppliers
$13.50/100 mL
696-62-8
357 suppliers
$5.00/1g
1879-16-9
123 suppliers
$10.00/1g