2-[3-(TRIFLUOROMETHYL)PHENOXY]NICOTINIC ACID synthesis
- Product Name:2-[3-(TRIFLUOROMETHYL)PHENOXY]NICOTINIC ACID
- CAS Number:36701-89-0
- Molecular formula:C13H8F3NO3
- Molecular Weight:283.2
2942-59-8
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![3-Pyridinecarboxamide, N-(1,1-dimethyl-2-propyn-1-yl)-2-[3-(trifluoromethyl)phenoxy]-](http://hg.y866.cn/chemistry/CAS/20210305/GIF/77616-34-3.gif)
77616-34-3
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36701-89-0
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$68.10/100mg
Yield:36701-89-0 91.2%
Reaction Conditions:
with sodium methylate in methanol;
Steps:
1.a Preparation of 2(3-trifluoromethylphenoxy)N (1,1-dimethylpropargyl)nicotinamide (Compound 3 herein)
(a) To a flask containing a solution of 45.4 grams (0.21 mole) 25% sodium methoxide in 100 milliliters of methanol were added 81.5 grams (0.5 mole) 3-trifluoromethylphenol and 15.8 grams (0.1 mole) 2-chloronicotinic acid. The reaction mass was heated and the methanol distilled off. The pot temperature was raised to 180° C. and held at that level for one hour. The mixture was then cooled to 100° C. and poured into 500 milliliters ice water. The aqueous mixture was extracted with 3 portions of 200 milliliters each, of diethyl ether, then acidified with glacial acetic acid. A solid precipitated, which was filtered, washed with water and dried, to give 25.8 grams (91.2% of theoretical yield) of 2-(3-trifluoromethylphenoxy)nicotinic acid, m.p. 149°-151° C.
References:
US4251263,1981,A
2942-59-8
831 suppliers
$5.00/25g
98-17-9
452 suppliers
$5.00/10g
36701-89-0
53 suppliers
$68.10/100mg
59-67-6
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36701-89-0
53 suppliers
$68.10/100mg
2942-59-8
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72332-16-2
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36701-89-0
53 suppliers
$68.10/100mg
83164-33-4
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367-25-9
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36701-89-0
53 suppliers
$68.10/100mg