2,6-DICHLORO-4-(TRIFLUOROMETHYL)NICOTINAMIDE synthesis

Yield: 90.09%

Reaction Conditions:

with sulfuric acid at 100; for 1 h;

Steps:

1.3 (3) Preparation of 2,6-dichloro-4-(trifluoromethyl)nicotinamide
500 mL round bottom flask, 79.6 g (330 mmo 1) of 2,6-dichloro-3-cyano-4-(trifluoromethyl)pyridine concentrated sulfuric acid 400 grams heated to 100 degrees with stirring l h, after the reaction was added to the water to precipitate a solid, filtered and washed, dried to give a white solid 77 grams, yield 90.09%.

References:

Hebei Lan Tai Chemical Technology Co., Ltd.;Guo Ming;Meng Shuiqiang;Tian Penghui;Hou Jianjun CN107382848, 2017, A Location in patent:Paragraph 0043; 0048-0049