2-(dimethylamino)propanoic acid synthesis
- Product Name:2-(dimethylamino)propanoic acid
- CAS Number:19701-89-4
- Molecular formula:C5H11NO2
- Molecular Weight:117.15
82614-49-1
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19701-89-4
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Yield:19701-89-4 100%
Reaction Conditions:
Stage #1: ethyl 2-(N,N-dimethylamino)-propionatewith water;sodium hydroxide at 20; for 4.5 h;
Stage #2: with hydrogenchloride in water;
Steps:
60
[0304] An aqueous 10 wt% NaOH (0.15 g/1.5 ml) solution was added to Compound 2 (0.375 g, 2.58 mmol) and stirredfor 4.5 hours at room temperature. The reaction solution was poured onto ice and pH thereof was adjusted to approximately2 using a 1 M aqueous HCl solution. After adding EA thereto, an aqueous layer was washed several times and then aseparated aqueous layer was vacuum evaporated. A concentrated solution was dissolved in MC and MeOH and thenundissolved solids were removed by filtration. The filtered solution was vacuum evaporated and then intactly collected.White solid (quantitative)1H NMR (300 MHz, DMSO) δ 4.06 (q, J= 7.1 Hz, 1H) 2.74 (s, 6H), 1.44 (d, J = 7.1 Hz, 3H)
References:
EP3091003,2016,A1 Location in patent:Paragraph 0302; 0304
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19701-89-4
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