ChemicalBook CAS DataBase List 2-tert-Butyl-4,6-dimethylphenol

2-tert-Butyl-4,6-dimethylphenol synthesis

11synthesis methods

Product Name:2-tert-Butyl-4,6-dimethylphenol
CAS Number:1879-09-0
Molecular formula:C12H18O
Molecular Weight:178.27

2-(tert-Butyl)-4,6-dimethylphenol is a very important pharmaceutical intermediate, which can be used as a new type of high temperature resistant aviation fuel antioxidant and acrylic acid polymerization inhibitor. It can be synthesized by alkylation reaction with 2,4-dimethylphenol and isobutylene as raw materials and concentrated sulfuric acid as catalyst.

105-67-9 Synthesis

105-67-9
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$14.00/1g

115-11-7
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1879-09-0
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$31.00/25g

Yield:1879-09-0 253 g (86.6%)

Reaction Conditions:

with toluene-4-sulfonic acid in toluene

Steps:

I 2,4-Dimethyl-6-t-butylphenol.
EXAMPLE I 2,4-Dimethyl-6-t-butylphenol. To a 1 liter flask equipped with a condenser, over-head stirrer, and gas inlet tube was added 2,4-dimethylphenol (200 g, 1.64 m.), toluene (400 ml), and p-toluenesulfonic acid (10 g). After heating this solution to reflux, isobutylene was added continuously for 14 hrs. Upon cooling, the solution was washed twice with water (400 ml), dried (MgSO₄), and the solvent evaporated to afford a dark brown liquid. GC confirmed that this liquid was about 72% product. Distillation afforded 253 g (86.6%) of clear product which was shown to be 97% pure by GC.

References:

The B. F. Goodrich Company US4163008, 1979, A

128-37-0 Synthesis