3,5-DICHLORO-4-PROPOXYBENZOIC ACID synthesis

Yield:-

Reaction Conditions:

with lithium hydroxide in tetrahydrofuran;water at 25; for 12 h;

Steps:

iv

General procedure: Methyl 3,5-dichloro-4-(cyclopentyloxy)benzoate (1.05 g, 3.63 mmol) and lithium hydroxide (174 mg, 7.26 mmol) were combined in tetrahydrofuran (10 mL), and water (1.5 mL) was added dropwise until a solution formed. The resultant mixture was stirred at room temperature for 12 h. The tetrahydrofuran was removed in vacuo and the residue acidified using aqueous 1M hydrochloric acid. The resultant precipitate was filtered to afford 3,5-dichloro-4-(cyclopentyloxy)benzoic acid

References:

Clarke, Earl;Jarvis, Christopher I.;Goncalves, Maria B.;Kalindjian, S. Barret;Adams, David R.;Brown, Jane T.;Shiers, Jason J.;Taddei, David M.A.;Ravier, Elodie;Barlow, Stephanie;Miller, Iain;Smith, Vanessa;Borthwick, Alan D.;Corcoran, Jonathan P.T. [Bioorganic and Medicinal Chemistry,2018,vol. 26,# 4,p. 798 - 814]