3-Bromo-N-methyl-5-nitrobenzamide synthesis
- Product Name:3-Bromo-N-methyl-5-nitrobenzamide
- CAS Number:90050-52-5
- Molecular formula:C8H7BrN2O3
- Molecular Weight:259.06
6307-87-5
119 suppliers
$9.00/1g
74-89-5
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$13.44/25ML
90050-52-5
33 suppliers
$45.00/100mg
Yield:90050-52-5 94.6%
Reaction Conditions:
with 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran;methanol at 20;Reagent/catalyst;Solvent;
Steps:
3 (S3) Preparation of N-methyl-3-bromo-5-nitrobenzamide (formula V.).
Methyl 3-bromo-5-nitrobenzoate (formula IV.) 26g was added to a 250mL three-mouth flask, tetrahydrofuran 60mL, 1,8-diazabicyclo [5.4.0] undecyl-7-alkene 3mL, stirred and dissolved at room temperature; Slowly add 12mol/L of methanamine methanol solution 60 mL; Drip, room temperature stirring overnight, after the end of the reaction, the reaction solution is concentrated, add 1mol / L aqueous hydrochloric acid solution 100mL beating, filtering, filter cake drying, to give a yellow solid compound N- methyl-3-bromo-5-nitrobenzamide 24.5g, purity of 99.2%, yield of 94.6%.
References:
CN114716340,2022,A Location in patent:Paragraph 0069-0075
6307-83-1
220 suppliers
$5.00/250mg
74-89-5
0 suppliers
$13.44/25ML
90050-52-5
33 suppliers
$45.00/100mg
74-89-5
0 suppliers
$13.44/25ML
90050-52-5
33 suppliers
$45.00/100mg
6307-83-1
220 suppliers
$5.00/250mg
90050-52-5
33 suppliers
$45.00/100mg