3-(DIMETHYLAMINO)-1-PHENYL-2-PROPEN-1-ONE synthesis
- Product Name:3-(DIMETHYLAMINO)-1-PHENYL-2-PROPEN-1-ONE
- CAS Number:1201-93-0
- Molecular formula:C11H13NO
- Molecular Weight:175.23
4637-24-5
98-86-2
1201-93-0
In a 100 mL dry round-bottomed flask, acetophenone (1.08 g, 9 mmol) and N,N-dimethylformamide dimethyl acetal (3.9 mL, 30 mmol) were added with 30 mL of xylene as solvent. The reaction mixture was refluxed at 140 °C for 12 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and the heating was stopped after confirming the completion of the reaction. The solvent was removed by distillation under reduced pressure and the resulting crude product was purified by fast column chromatography to afford 3-(dimethylamino)-1-phenyl-2-propen-1-one (1.48 g, 97% yield) as a light yellow solid.
1794-48-5
20 suppliers
$45.00/10mg
1201-93-0
97 suppliers
$17.00/250mg
Yield:-
Steps:
Multi-step reaction with 2 steps
1.1: sodium methylate / methanol / 0.5 h / 20 °C
1.2: 1 h / 20 °C
2.1: sodium carbonate / ethanol / 2 h / 85 °C
References:
Chen, Jinshan;Properzi, Roberta;Uccello, Daniel P.;Young, Jennifer A.;Dushin, Russell G.;Starr, Jeremy T. [Organic Letters,2014,vol. 16,# 16,p. 4146 - 4149]
4637-24-5
642 suppliers
$5.00/25g
98-86-2
796 suppliers
$9.00/5g
1201-93-0
97 suppliers
$17.00/250mg
75-52-5
0 suppliers
$31.20/100g
124-40-3
548 suppliers
$18.00/100ml
98-86-2
796 suppliers
$9.00/5g
1201-93-0
97 suppliers
$17.00/250mg
14677-24-8
2 suppliers
inquiry
124-40-3
548 suppliers
$18.00/100ml
1201-93-0
97 suppliers
$17.00/250mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](http://hg.y866.cn/chemistry/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
1201-93-0
97 suppliers
$17.00/250mg